HitPredict

Interactor 1: TBC25 (Q3MII6)
TBC1 domain family member 25
Gene: TBC1D25

Interactor 2: GBRL1 (Q9H0R8)
Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Gene: GABARAPL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

Property	Details
Experiments	28514442, 32296183, 33961781, 22354992, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid array, two hybrid prey pooling approach, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 688 Hs			1 117
+	Hs
		891174 TBC25_HUMAN (1-688): 0: 735: 100.00		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		306201 TBC25_HUMAN (1-688): 0: 735: 100.00		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		1109688 TBC25_HUMAN (1-688): 0: 735: 100.00		MLP3C_HUMAN (5-116): 1.61e-44: 143: 39.47
+	Hs
		1109691 TBC25_HUMAN (1-688): 0: 735: 100.00		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1109689 TBC25_HUMAN (1-688): 0: 735: 100.00		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		1315253 TB10A_HUMAN (127-614): 4.12e-95: 305: 16.53		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		891232 TBC15_HUMAN (137-475): 2.54e-86: 287: 31.11		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1253208 TBC15_HUMAN (137-475): 2.54e-86: 287: 31.11		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		306240 TBC15_HUMAN (137-475): 2.54e-86: 287: 31.11		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		1315254 TB10A_HUMAN (127-614): 4.12e-95: 305: 16.53		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Dm
		1364630 Q9VPL5_DROME (112-475): 1.79e-78: 266: 27.08		Q9VEG5_DROME (1-117): 1.86e-54: 167: 73.50
+	Hs
		1198509 TBCD1_HUMAN (78-609): 9.38e-74: 260: 16.42		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		1253202 TBC15_HUMAN (137-475): 2.54e-86: 287: 31.11		MLP3C_HUMAN (5-116): 1.61e-44: 143: 39.47
+	Hs
		1253204 TBC15_HUMAN (137-475): 2.54e-86: 287: 31.11		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		1117430 TB10B_HUMAN (114-617): 1.78e-72: 252: 15.89		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		1328034 TBC17_HUMAN (194-550): 1.7e-72: 249: 31.22		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		1198510 TBCD1_HUMAN (78-609): 9.38e-74: 260: 16.42		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1117431 TB10B_HUMAN (114-617): 1.78e-72: 252: 15.89		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1330629 TBC17_HUMAN (194-550): 1.7e-72: 249: 31.22		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1326155 TBC17_HUMAN (194-550): 1.7e-72: 249: 31.22		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62