Protein: RIPK1
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)

Gene: RIPK1
Organism: Mus musculus
Interactions: 42
UniProt ID: Q60855

Gene Ontology (top 5):
GO:0001934 - positive regulation of protein phosphorylation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005123 - death receptor binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1221632

FADD
FAS-associated death domain protein

14

20

Small-scale

0.978

High

669415

TNR1A
Tumor necrosis factor receptor superfamily member 1A

14

20

Small-scale

0.977

High

1221647

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

4

20

Small-scale

0.873

High

449245

TNFA
Tumor necrosis factor

6

14

Small-scale

0.723

High

1189707

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

2

Small-scale

0.691

High

1221644

TLR4
Toll-like receptor 4

1

20

Small-scale

0.691

High

1221457

TNAP3
Tumor necrosis factor alpha-induced protein 3

4

5

Small-scale

0.691

High

1058977

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

17

Small-scale

0.665

High

1034936

KPCT
Protein kinase C theta type

1

20

Small-scale

0.646

High

1221637

CAR11
Caspase recruitment domain-containing protein 11

1

12

Small-scale

0.646

High

312499

NEMO
NF-kappa-B essential modulator

3

20

Small-scale

0.640

High

313068

CRADD
Death domain-containing protein CRADD

1

1

Small-scale

0.618

High

908801

NEK1
Serine/threonine-protein kinase Nek1

1

20

Small-scale

0.618

High

1209174

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

Small-scale

0.618

High

1221631

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

20

Small-scale

0.618

High

1221635

TCAM1
TIR domain-containing adapter molecule 1

1

13

Small-scale

0.618

High

1221641

TLR3
Toll-like receptor 3

1

20

Small-scale

0.618

High

1221645

ZBP1
Z-DNA-binding protein 1

1

3

Small-scale

0.618

High

313447

CASP8
Caspase-8

3

9

Small-scale

0.617

High

1221648

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.613

High

1221636

ITCH
E3 ubiquitin-protein ligase Itchy

2

12

Small-scale

0.601

High

1000254

TANK
TRAF family member-associated NF-kappa-B activator

2

1

Small-scale

0.584

High

1221630

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

18

Small-scale

0.575

High

811907

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.536

High

866566

TNR4
Tumor necrosis factor receptor superfamily member 4

1

19

Small-scale

0.536

High

1221640

ATG5
Autophagy protein 5

1

2

Small-scale

0.536

High

1221424

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

14

Small-scale

0.501

High

1180420

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

1

13

Small-scale

0.500

High

1221646

RNF11
RING finger protein 11

1

10

Small-scale

0.489

High

532190

IL1B
Interleukin-1 beta

1

4

Small-scale

0.479

High

999840

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

1188172

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

1190386

TAXB1
Tax1-binding protein 1 homolog

1

20

Small-scale

0.479

High

1221633

SQSTM
Sequestosome-1

1

9

Small-scale

0.479

High

1221634

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

Small-scale

0.479

High

1221638

DNM1L
Dynamin-1-like protein

1

7

Small-scale

0.479

High

1221639

OPTN
Optineurin

1

20

Small-scale

0.479

High

1221642

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

5

Small-scale

0.479

High

755325

INAR1
Interferon alpha/beta receptor 1

1

9

Small-scale

0.437

High

1169542

TRI72
Tripartite motif-containing protein 72

1

15

Small-scale

0.437

High

1221643

XPO7
Exportin-7

1

5

High-throughput

0.407

High


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Last updated: 11Aug2025