HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 25247294, 28977666, 9804427, 32744500, 25593309, 40437099, 9790534, 20693977, 9885572, 22075476, 21670149, 26496610, 27616479, 28514442, 12920132, 10220385, 26949739, 24981860, 33961781, 35271311 and 7 others

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Identification Methods affinity chromatography technology, cross-linking study, pull down, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hist_deacetyl~PHD
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 11 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 482
Hs

1 1912
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+ Ce
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Last updated: 11Aug2025