HitPredict

Interactor 1: CHD5 (Q8TDI0)
Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.-) (ATP-dependent helicase CHD5)
Gene: CHD5

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25247294
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Hist_deacetyl~PHD
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling and 2 others more... GO:0016581 - NuRD complex GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1954 Hs			1 488
+	Hs
		1109925 CHD5_HUMAN (1-1954): 0: 1739: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		59100 CHD5_MOUSE (1-1944): 0: 1669: 92.51		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Mm
		59097 CHD5_MOUSE (1-1944): 0: 1669: 92.51		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1088484 CHD3_HUMAN (29-1952): 0: 1547: 66.80		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1132869 CHD4_HUMAN (85-1916): 0: 1489: 71.41		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1088327 CHD3_HUMAN (29-1952): 0: 1547: 66.80		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		1000005 Q5DTP7_MOUSE (3-1907): 0: 1471: 68.32		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1109728 CHD4_HUMAN (85-1916): 0: 1489: 71.41		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		148708 CHD4_MOUSE (3-1907): 0: 1468: 68.69		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Dm
		356804 CHDM_DROME (16-1942): 0: 1334: 49.64		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		243693 SMCA5_HUMAN (553-1645): 0: 736: 25.48		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Dm
		1173920 ISWI_DROME (591-1661): 0: 729: 25.60		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		1110098 CHD8_HUMAN (458-1682): 0: 720: 25.93		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		160081 CHD1_HUMAN (501-1739): 0: 657: 29.51		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Sp
		148907 HRP3_SCHPO (504-1616): 0: 727: 29.00		PHD1_SCHPO (7-411): 0: 519: 52.56
+	Mm
		61330 CHD6_MOUSE (127-1683): 0: 775: 23.84		HDAC4_MOUSE (1-377): 6.15e-133: 412: 23.89
+	Sp
		149141 HRP1_SCHPO (494-1691): 0: 663: 27.37		PHD1_SCHPO (7-411): 0: 519: 52.56
+	Mm
		1068807 CHD8_MOUSE (42-1682): 0: 728: 21.67		HDAC4_MOUSE (1-377): 6.15e-133: 412: 23.89
+	Ce
		196420 CHD3_CAEEL (1277-1927): 1.38e-83: 307: 25.80		HDA1_CAEEL (7-456): 0: 595: 64.02
+	Ce
		110290 LE418_CAEEL (1309-1925): 3.31e-82: 303: 25.42		HDA1_CAEEL (7-456): 0: 595: 64.02