HitPredict

Interactor 1: KCC2B (Q13554)
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene: CAMK2B

Interactor 2: KCC2D (Q13557)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Gene: CAMK2D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.974

The method score is based on:

Property Details
Experiments 29426014, 32296183, 32707033, 28514442, 33961781, 38334954, 20668654, unassigned1304, unassigned3799
Identification Methods affinity chromatography technology, two hybrid, cross-linking study, cosedimentation in solution, anti tag coimmunoprecipitation, validated two hybrid, pull down, two hybrid array, two hybrid prey pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CaMKII_AD~CaMKII_AD, CaMKII_AD~Pkinase, Pkinase~Pkinase
Common GO terms GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 12 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 666
Hs

1 499
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Last updated: 11Aug2025