HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: K2C78 (Q8N1N4)
Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)
Gene: KRT78

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 520
+	Hs
		1030979 CUL2_HUMAN (1-745): 0: 839: 100.00		K22O_HUMAN (49-437): 5.24e-125: 381: 58.61
+	Hs
		777456 CUL2_HUMAN (1-745): 0: 839: 100.00		K22E_HUMAN (83-427): 1.06e-121: 372: 55.65
+	Hs
		407441 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C1_HUMAN (76-442): 1.8e-110: 343: 56.95
+	Hs
		1030981 CUL4A_HUMAN (4-745): 0: 770: 26.86		K22O_HUMAN (49-437): 5.24e-125: 381: 58.61
+	Hs
		341766 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C75_HUMAN (2-510): 6.76e-98: 308: 47.44
+	Hs
		777455 CUL1_HUMAN (6-745): 0: 770: 36.24		K22E_HUMAN (83-427): 1.06e-121: 372: 55.65
+	Hs
		777458 CUL4A_HUMAN (4-745): 0: 770: 26.86		K22E_HUMAN (83-427): 1.06e-121: 372: 55.65
+	Hs
		1112863 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C71_HUMAN (4-501): 6.14e-90: 287: 48.83
+	Hs
		407440 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C1_HUMAN (76-442): 1.8e-110: 343: 56.95
+	Hs
		407443 CUL4A_HUMAN (4-745): 0: 770: 26.86		K2C1_HUMAN (76-442): 1.8e-110: 343: 56.95
+	Hs
		876465 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C6C_HUMAN (76-448): 2.41e-83: 270: 59.52
+	Hs
		385268 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C6A_HUMAN (76-448): 2.28e-82: 268: 59.79
+	Hs
		566370 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C5_HUMAN (6-427): 6.97e-82: 267: 51.69
+	Hs
		341765 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C75_HUMAN (2-510): 6.76e-98: 308: 47.44
+	Hs
		341768 CUL4A_HUMAN (4-745): 0: 770: 26.86		K2C75_HUMAN (2-510): 6.76e-98: 308: 47.44
+	Hs
		1007514 CUL4A_HUMAN (4-745): 0: 770: 26.86		KRT85_HUMAN (3-481): 1.02e-97: 306: 41.36
+	Hs
		407285 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C6B_HUMAN (76-448): 1.08e-83: 271: 59.25
+	Hs
		876464 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C6C_HUMAN (76-448): 2.41e-83: 270: 59.52
+	Hs
		385267 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C6A_HUMAN (76-448): 2.28e-82: 268: 59.79
+	Hs
		566369 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C5_HUMAN (6-427): 6.97e-82: 267: 51.69