HitPredict

Interactor 1: PTC1 (Q13635)
Protein patched homolog 1 (PTC) (PTC1)
Gene: PTCH1

Interactor 2: PLXA1 (Q9UIW2)
Plexin-A1 (Semaphorin receptor NOV)
Gene: PLXNA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1447 Hs			1 1896
+	Hs
		907902 PTC1_HUMAN (1-1447): 0: 1542: 100.00		PLXA3_HUMAN (39-1896): 0: 2342: 67.15
+	Hs
		175364 PTC1_HUMAN (1-1447): 0: 1542: 100.00		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		1116337 PTC1_HUMAN (1-1447): 0: 1542: 100.00		PLXD1_HUMAN (45-1893): 0: 1845: 31.33
+	Hs
		1098310 PTC1_HUMAN (1-1447): 0: 1542: 100.00		SEM3B_HUMAN (16-547): 4.39e-133: 436: 17.50
+	Hs
		1116307 PTC1_HUMAN (1-1447): 0: 1542: 100.00		SEM4B_HUMAN (23-769): 1.99e-124: 415: 16.09
+	Hs
		1116300 PTC1_HUMAN (1-1447): 0: 1542: 100.00		SEM6A_HUMAN (6-549): 4.24e-119: 405: 16.50
+	Hs
		1116287 PTC1_HUMAN (1-1447): 0: 1542: 100.00		SEM3C_HUMAN (40-545): 1.8e-121: 404: 15.43
+	Hs
		1049146 PTC1_HUMAN (1-1447): 0: 1542: 100.00		RON_HUMAN (815-1212): 5.52e-85: 310: 25.24
+	Dm
		56694 PTC_DROME (48-1283): 0: 959: 38.15		A1ZAF5_DROME (44-541): 1e-33: 143: 18.06