HitPredict

Interactor 1: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Interactor 2: Q8N4I8 (Q8N4I8)
KLHL3 protein
Gene: KLHL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BACK~BTB, BTB~BTB
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 301
+	Hs
		1120826 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLHL3_HUMAN (1-301): 3.39e-120: 358: 100.00
+	Hs
		1120830 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH20_HUMAN (7-297): 3.32e-114: 343: 45.02
+	Hs
		307182 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLHL2_HUMAN (3-301): 3.69e-113: 340: 70.00
+	Hs
		1377320 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		KLH20_HUMAN (7-297): 3.32e-114: 343: 45.02
+	Hs
		1120768 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH17_HUMAN (29-298): 9.54e-106: 323: 51.48
+	Hs
		1120764 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH12_HUMAN (30-295): 8.92e-103: 313: 45.87
+	Hs
		1120769 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH24_HUMAN (30-298): 3.52e-98: 302: 40.15
+	Hs
		1120822 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH13_HUMAN (5-297): 1.19e-95: 297: 30.51
+	Dm
		1374538 KLHDB_DROME (3-566): 3.83e-171: 500: 42.23		KLHDB_DROME (18-285): 1.86e-104: 319: 46.27
+	Hs
		1120821 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLHL9_HUMAN (3-296): 4.96e-95: 294: 30.41
+	Hs
		1164636 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		KLH24_HUMAN (30-298): 3.52e-98: 302: 40.15
+	Hs
		1120833 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		IPP_HUMAN (14-295): 7.93e-93: 287: 32.75
+	Hs
		1120765 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH26_HUMAN (11-297): 1.33e-91: 285: 30.31
+	Dm
		980055 KELC_DROME (9-567): 1.41e-157: 489: 40.04		KELC_DROME (2-301): 6.65e-98: 316: 50.50
+	Hs
		1120827 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH21_HUMAN (19-299): 1.06e-89: 280: 32.62
+	Hs
		1049221 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KEAP1_HUMAN (3-286): 3.33e-89: 279: 32.41
+	Hs
		1377325 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		IPP_HUMAN (14-295): 7.93e-93: 287: 32.75
+	Hs
		1121511 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		KLH26_HUMAN (11-297): 1.33e-91: 285: 30.31
+	Hs
		1356007 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		KLH21_HUMAN (19-299): 1.06e-89: 280: 32.62