HitPredict

Interactor 1: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Interactor 2: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38334954
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~CH
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 803 Hs			1 4684
+	Hs
		584543 VAV_HUMAN (1-754): 1.26e-102: 337: 17.25		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		1143279 ARHG4_HUMAN (24-659): 8.54e-103: 333: 19.03		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		1143227 Q96D37_HUMAN (55-754): 1.93e-84: 287: 15.45		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		1143235 FGD4_HUMAN (102-638): 8.72e-80: 274: 15.56		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		73658 PKHG2_HUMAN (243-649): 4.14e-79: 280: 21.96		B2R8Y4_HUMAN (166-891): 3.47e-121: 410: 25.73
+	Hs
		1061557 PKHG2_HUMAN (243-649): 4.14e-79: 280: 21.96		ACTN3_HUMAN (166-891): 1.55e-120: 408: 25.86
+	Mm
		60059 KALRN_MOUSE (31-788): 9.7e-70: 253: 15.23		F6Q750_MOUSE (944-2723): 4.61e-116: 419: 25.87
+	Mm
		60097 KALRN_MOUSE (31-788): 9.7e-70: 253: 15.23		SPTB2_MOUSE (1005-2737): 1.53e-30: 136: 10.11
+	Mm
		60100 KALRN_MOUSE (31-788): 9.7e-70: 253: 15.23		Q68FG2_MOUSE (1516-3107): 9.4e-20: 100: 11.25
+	Hs
		1028778 ITSN1_HUMAN (26-244): 4.97e-10: 65.5: 14.63		SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83
+	Hs
		1040391 ITSN2_HUMAN (41-282): 2.76e-10: 66.2: 18.08		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90
+	Hs
		1040304 ITSN1_HUMAN (26-244): 4.97e-10: 65.5: 14.63		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90