HitPredict

Interactor 1: WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene: WRN

Interactor 2: SKAP1 (Q86WV1)
Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)
Gene: SKAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1432 Hs			1 359
+	Hs
		315747 RECQ4_HUMAN (530-878): 2.43e-118: 402: 29.95		SKAP1_HUMAN (1-359): 3.13e-126: 368: 100.00
+	Hs
		316319 RECQ5_HUMAN (525-1181): 5.16e-145: 470: 24.96		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		1234849 DDX42_HUMAN (309-900): 1.68e-131: 432: 13.75		PKHA7_HUMAN (19-290): 4.09e-36: 141: 14.33
+	Hs
		1294118 DDX42_HUMAN (309-900): 1.68e-131: 432: 13.75		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		141529 DDX3X_HUMAN (354-901): 2.15e-117: 385: 14.68		PKHA7_HUMAN (19-290): 4.09e-36: 141: 14.33
+	Hs
		1234890 DDX17_HUMAN (469-955): 7.23e-116: 383: 16.54		PKHA7_HUMAN (19-290): 4.09e-36: 141: 14.33
+	Hs
		926411 BLM_HUMAN (221-1231): 1.52e-120: 412: 20.21		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		141439 DDX3X_HUMAN (354-901): 2.15e-117: 385: 14.68		BTK_HUMAN (105-356): 9.65e-33: 130: 12.72
+	Hs
		608636 DDX5_HUMAN (469-897): 9.25e-111: 365: 16.78		PKHA7_HUMAN (19-290): 4.09e-36: 141: 14.33
+	Hs
		1270785 DDX46_HUMAN (278-1201): 2.37e-116: 392: 12.54		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Mm
		778170 DDX5_MOUSE (469-897): 9.01e-112: 368: 17.00		BTK_MOUSE (105-356): 1.74e-32: 130: 12.37
+	Hs
		141661 DDX3X_HUMAN (354-901): 2.15e-117: 385: 14.68		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		1369388 DDX17_HUMAN (469-955): 7.23e-116: 383: 16.54		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		193147 DDX3Y_HUMAN (354-926): 1.15e-114: 377: 14.03		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		854932 RECQ1_HUMAN (479-1117): 1.3e-110: 366: 26.61		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		608750 DDX5_HUMAN (469-897): 9.25e-111: 365: 16.78		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		1434024 EXD2_HUMAN (73-227): 1.44e-11: 71.2: 32.72		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56