Protein: BTK
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) (Kinase EMB)

Gene: BTK
Organism: Mus musculus
Interactions: 44
UniProt ID: P35991

Gene Ontology (top 5):
GO:0001780 - neutrophil homeostasis
GO:0001805 - positive regulation of type III hypersensitivity
GO:0001812 - positive regulation of type I hypersensitivity
GO:0001818 - negative regulation of cytokine production
GO:0002344 - B cell affinity maturation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686939

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.754

High

778180

BLNK
B-cell linker protein

2

20

Small-scale

0.754

High

778155

BTK
Tyrosine-protein kinase BTK

2

20

Small-scale

0.712

High

778176

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

16

Small-scale

0.618

High

778179

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

778164

WASP
Actin nucleation-promoting factor WAS

2

20

Small-scale

0.596

High

778167

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.590

High

778157

STAT3
Signal transducer and activator of transcription 3

1

17

Small-scale

0.575

High

648035

MYD88
Myeloid differentiation primary response protein MyD88

1

15

Small-scale

0.536

High

778173

TCAM1
TIR domain-containing adapter molecule 1

1

11

Small-scale

0.536

High

693154

TNR5
Tumor necrosis factor receptor superfamily member 5

1

13

Small-scale

0.515

High

683135

CD19
B-lymphocyte antigen CD19

1

2

Small-scale

0.479

High

778160

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

Small-scale

0.479

High

778161

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

3

Small-scale

0.479

High

778168

TRAF3
TNF receptor-associated factor 3

1

19

Small-scale

0.479

High

778172

ARI3A
AT-rich interactive domain-containing protein 3A

1

1

Small-scale

0.479

High

778178

Q9ERL0
Btk-PH-domain binding protein

1

6

Small-scale

0.479

High

663326

IRF2
Interferon regulatory factor 2

1

0

Small-scale

0.458

High

778177

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

1

0

Small-scale

0.458

High

778181

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.458

High

98123

E9Q604
Integrin alpha M

1

6

High-throughput

0.457

High

421219

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.457

High

502197

H2AZ
Histone H2A.Z

1

1

High-throughput

0.457

High

778156

SMBP2
DNA-binding protein SMUBP-2

1

1

High-throughput

0.457

High

778158

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

2

High-throughput

0.457

High

778159

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.457

High

778162

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.457

High

778163

TBA1A
Tubulin alpha-1A chain

1

14

High-throughput

0.457

High

778165

CBX1
Chromobox protein homolog 1

1

5

High-throughput

0.457

High

778169

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.457

High

778170

DDX5
Probable ATP-dependent RNA helicase DDX5

1

4

High-throughput

0.457

High

778171

MRC1
Macrophage mannose receptor 1

1

4

High-throughput

0.457

High

778174

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

7

High-throughput

0.457

High

778182

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.457

High

570733

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.438

High

578743

GLNA
Glutamine synthetase

1

0

High-throughput

0.438

High

778166

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.438

High

236721

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

5

High-throughput

0.417

High

712086

FRIL1
Ferritin light chain 1

1

2

High-throughput

0.417

High

778183

AP3B1
AP-3 complex subunit beta-1

1

7

High-throughput

0.417

High

148776

MA2B1
Lysosomal alpha-mannosidase

1

0

High-throughput

0.238

Low

702207

LYOX
Protein-lysine 6-oxidase

1

0

High-throughput

0.238

Low

778175

Q8BTX4
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025