HitPredict

Interactor 1: HES1 (Q14469)
Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)
Gene: HES1

Interactor 2: HEY1 (Q9Y5J3)
Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)
Gene: HEY1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.918

The method score is based on:

Property Details
Experiments 26068074, 19802006, 27129302, 33961781, unassigned3799
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hairy_orange~Hairy_orange, HLH~HLH
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 10 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 280
Hs

1 304
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Gg
+ Gg
+ Dr
+ Mm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dr

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Last updated: 11Aug2025