Protein: HES6
Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)

Gene: HES6
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q96HZ4

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1126803

HES1
Transcription factor HES-1

3

17

Small-scale

0.839

High

1393916

NGN3
Neurogenin-3

2

19

High-throughput

0.811

High

725103

HXC8
Homeobox protein Hox-C8

1

7

High-throughput

0.691

High

1151973

TWST1
Twist-related protein 1

1

19

Small-scale

0.691

High

1047854

TLE1
Transducin-like enhancer protein 1

3

20

Small-scale

0.669

High

1393907

HES6
Transcription cofactor HES-6

1

18

Small-scale

0.618

High

956446

RAB2A
Ras-related protein Rab-2A

2

2

High-throughput

0.606

High

1048173

TLE4
Transducin-like enhancer protein 4

2

20

High-throughput

0.601

High

1392029

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.580

High

950863

KR109
Keratin-associated protein 10-9

2

3

High-throughput

0.553

High

896434

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.536

High

1048062

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.536

High

1061823

TLE5
TLE family member 5

1

20

High-throughput

0.536

High

1094611

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

1

High-throughput

0.536

High

1259421

TBA1A
Tubulin alpha-1A chain

1

6

High-throughput

0.536

High

1393909

ACBD6
Acyl-CoA-binding domain-containing protein 6

1

3

High-throughput

0.536

High

1393911

ESRP2
Epithelial splicing regulatory protein 2

1

1

High-throughput

0.536

High

1393912

TF7L2
Transcription factor 7-like 2

1

2

High-throughput

0.536

High

159015

ZN195
Zinc finger protein 195

1

0

High-throughput

0.513

High

298616

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.513

High

703026

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.513

High

1152944

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.513

High

1368817

N42L2
NEDD4-binding protein 2-like 2

1

0

High-throughput

0.513

High

1393913

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.513

High

1393915

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.513

High

1393917

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

691822

MK03
Mitogen-activated protein kinase 3

1

1

Small-scale

0.501

High

997941

CSK21
Casein kinase II subunit alpha

1

11

Small-scale

0.501

High

1327134

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.489

High

242585

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

1067601

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1368454

CBP
CREB-binding protein

1

2

Small-scale

0.479

High

1393914

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.316

High

66760

RGPD3
RanBP2-like and GRIP domain-containing protein 3

1

0

High-throughput

0.279

Low

213229

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.279

Low

1085193

WASC5
WASH complex subunit 5

1

0

High-throughput

0.279

Low

1153214

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.279

Low

1187167

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

0

High-throughput

0.279

Low

1244266

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.279

Low

1246929

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.279

Low

1290468

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.279

Low

1307125

RHPN2
Rhophilin-2

1

0

High-throughput

0.279

Low

1359633

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.279

Low

1393908

GCP6
Gamma-tubulin complex component 6

1

0

High-throughput

0.279

Low

1393910

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025