Protein: HES1
Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)

Gene: HES1
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q14469

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001222 - transcription corepressor binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001709 - cell fate determination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1126810

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

5

18

Small-scale

0.918

High

1126803

HES6
Transcription cofactor HES-6

3

17

Small-scale

0.839

High

1126798

HES1
Transcription factor HES-1

2

17

Small-scale

0.737

High

1037913

HEN2
Helix-loop-helix protein 2

1

20

Small-scale

0.724

High

1047816

TLE1
Transducin-like enhancer protein 1

5

20

Small-scale

0.711

High

1116409

FHL1
Four and a half LIM domains protein 1

1

1

High-throughput

0.656

High

1126808

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

18

Small-scale

0.647

High

1054707

SUH
Recombining binding protein suppressor of hairless

3

1

Small-scale

0.633

High

1126800

LMO3
LIM domain only protein 3

1

4

Small-scale

0.618

High

1126804

FANCE
Fanconi anemia group E protein

3

0

Small-scale

0.613

High

185194

FANCG
Fanconi anemia group G protein

2

0

Small-scale

0.593

High

187517

FANCA
Fanconi anemia group A protein

2

0

Small-scale

0.593

High

1126805

FANCF
Fanconi anemia group F protein

2

0

Small-scale

0.593

High

827780

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.578

High

1126802

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

Small-scale

0.578

High

1119469

RUNX2
Runt-related transcription factor 2

2

0

Small-scale

0.569

High

442714

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.537

High

1126806

FANCL
E3 ubiquitin-protein ligase FANCL

1

0

Small-scale

0.529

High

1047904

TLE2
Transducin-like enhancer protein 2

1

20

Small-scale

0.527

High

352705

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.508

High

652514

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

3

High-throughput

0.508

High

885774

KC1E
Casein kinase I isoform epsilon

1

2

High-throughput

0.508

High

1050996

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.508

High

1126807

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.508

High

1126809

ALK
ALK tyrosine kinase receptor

1

1

Small-scale

0.501

High

388581

SAMP
Serum amyloid P-component

1

0

High-throughput

0.486

High

408872

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.486

High

729834

1433B
14-3-3 protein beta/alpha

1

0

High-throughput

0.486

High

777609

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.486

High

1126801

APH1A
Gamma-secretase subunit APH-1A

1

1

High-throughput

0.481

High

253350

JAK2
Tyrosine-protein kinase JAK2

1

2

Small-scale

0.479

High

461479

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.479

High

487309

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.479

High

606763

CEBPB
CCAAT/enhancer-binding protein beta

1

5

Small-scale

0.479

High

761678

HSP74
Heat shock 70 kDa protein 4

1

5

Small-scale

0.479

High

992173

SKP1
S-phase kinase-associated protein 1

1

3

Small-scale

0.479

High

1109721

HDAC1
Histone deacetylase 1

1

6

Small-scale

0.479

High

1126799

FXL14
F-box/LRR-repeat protein 14

1

1

Small-scale

0.479

High

324863

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

507969

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

634735

ITAX
Integrin alpha-X

1

0

High-throughput

0.458

High

1025878

FANCC
Fanconi anemia group C protein

1

0

Small-scale

0.458

High

1109260

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.458

High

1112482

CUL1
Cullin-1

1

0

Small-scale

0.458

High

1117358

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

Small-scale

0.437

High

455972

ASGR2
Asialoglycoprotein receptor 2

1

0

High-throughput

0.251

Low

787549

TNR3
Tumor necrosis factor receptor superfamily member 3

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025