HitPredict

Interactor 1: HAIR (P14003)
Protein hairy
Gene: hry

Interactor 2: ESM3 (Q01068)
Enhancer of split m3 protein (E(spl)m3) (HLH-m3)
Gene: E(spl)m3-HLH

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	14871887
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0007399 - nervous system development GO:0046983 - protein dimerization activity GO:0050767 - regulation of neurogenesis
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 337 Dm			1 224
+	Dm
		569356 HAIR_DROME (1-337): 6.49e-82: 253: 100.00		DPN_DROME (7-222): 6.63e-43: 151: 22.87
+	Dm
		560200 HAIR_DROME (1-337): 6.49e-82: 253: 100.00		ESM8_DROME (5-224): 1.14e-40: 139: 26.24
+	Dm
		569350 HAIR_DROME (1-337): 6.49e-82: 253: 100.00		HAIR_DROME (9-211): 3.42e-34: 126: 24.16
+	Dm
		1028561 DPN_DROME (7-298): 1.57e-57: 194: 33.22		ESMC_DROME (4-224): 2.1e-49: 162: 39.01
+	Dm
		1028564 HEY_DROME (7-337): 1.63e-53: 183: 20.69		ESMC_DROME (4-224): 2.1e-49: 162: 39.01
+	Dm
		1175923 DPN_DROME (7-298): 1.57e-57: 194: 33.22		DPN_DROME (7-222): 6.63e-43: 151: 22.87
+	Hs
		1458602 HEY1_HUMAN (7-301): 8.1e-54: 180: 21.82		HEY2_HUMAN (2-223): 7.32e-46: 157: 18.34
+	Hs
		1126808 HES1_HUMAN (8-259): 1.55e-53: 179: 33.33		HEY2_HUMAN (2-223): 7.32e-46: 157: 18.34
+	Mm
		204426 BHE40_MOUSE (24-302): 8.99e-52: 178: 17.16		BHE40_MOUSE (4-216): 6.92e-45: 156: 23.18
+	Hs
		154917 BHE40_HUMAN (24-302): 8.18e-51: 175: 17.49		BHE40_HUMAN (4-216): 2.97e-45: 157: 23.18
+	Dm
		1175925 DPN_DROME (7-298): 1.57e-57: 194: 33.22		HEY_DROME (6-217): 1.34e-37: 137: 22.17
+	Hs
		1126810 HEY1_HUMAN (7-301): 8.1e-54: 180: 21.82		HES1_HUMAN (8-224): 4.33e-44: 150: 24.05
+	Hs
		1126798 HES1_HUMAN (8-259): 1.55e-53: 179: 33.33		HES1_HUMAN (8-224): 4.33e-44: 150: 24.05
+	Hs
		1491691 HEY1_HUMAN (7-301): 8.1e-54: 180: 21.82		HEY1_HUMAN (1-220): 3.66e-43: 149: 19.13
+	Hs
		155025 BHE40_HUMAN (24-302): 8.18e-51: 175: 17.49		BHE41_HUMAN (2-218): 5.69e-41: 147: 21.59
+	Hs
		1126803 HES1_HUMAN (8-259): 1.55e-53: 179: 33.33		HES6_HUMAN (7-224): 2.29e-39: 137: 22.97
+	Mm
		771401 HES1_MOUSE (8-246): 1.2e-53: 179: 33.59		HES6_MOUSE (4-224): 3.18e-36: 129: 22.22