Protein: HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2 (Cardiovascular helix-loop-helix factor 1) (hCHF1) (Class B basic helix-loop-helix protein 32) (bHLHb32) (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (hHRT2) (Protein gridlock homolog)

Gene: HEY2
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q9UBP5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458602

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

8

18

Small-scale

0.965

High

885438

HXA1
Homeobox protein Hox-A1

2

5

High-throughput

0.783

High

1216166

FHL5
Four and a half LIM domains protein 5

2

2

High-throughput

0.783

High

1447726

PDLI7
PDZ and LIM domain protein 7

2

0

High-throughput

0.742

High

1093989

TRAF1
TNF receptor-associated factor 1

3

3

High-throughput

0.675

High

354064

HAND1
Heart- and neural crest derivatives-expressed protein 1

1

19

Small-scale

0.647

High

1126808

HES1
Transcription factor HES-1

1

18

Small-scale

0.647

High

1331272

ARL10
ADP-ribosylation factor-like protein 10

4

4

High-throughput

0.630

High

693375

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

7

Small-scale

0.621

High

1414798

TRAF4
TNF receptor-associated factor 4

2

3

High-throughput

0.606

High

1439646

CHM1A
Charged multivesicular body protein 1a

2

0

High-throughput

0.602

High

925690

IST1
IST1 homolog

2

0

High-throughput

0.585

High

1293429

CARM1
Histone-arginine methyltransferase CARM1

2

0

High-throughput

0.585

High

844049

HD
Huntingtin

1

2

High-throughput

0.582

High

269410

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1388761

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

Small-scale

0.578

High

1372114

RBPMS
RNA-binding protein with multiple splicing

1

3

High-throughput

0.573

High

278441

NCOR1
Nuclear receptor corepressor 1

1

1

Small-scale

0.561

High

685970

KRA59
Keratin-associated protein 5-9

2

4

High-throughput

0.553

High

1059756

KRA11
Keratin-associated protein 1-1

2

3

High-throughput

0.553

High

1186612

KRA61
Keratin-associated protein 6-1

2

3

High-throughput

0.553

High

1186721

KRA62
Keratin-associated protein 6-2

2

5

High-throughput

0.553

High

1307101

KRA81
Keratin-associated protein 8-1

2

1

High-throughput

0.553

High

1419086

KRA44
Keratin-associated protein 4-4

2

4

High-throughput

0.553

High

446075

ENOA
Alpha-enolase

1

1

High-throughput

0.541

High

927591

ATX1
Ataxin-1

1

2

High-throughput

0.541

High

289288

SPB7
Serpin B7

1

6

High-throughput

0.536

High

538049

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.536

High

1312437

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.529

High

180610

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

1110145

HDAC1
Histone deacetylase 1

1

6

Small-scale

0.501

High

276640

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.489

High

1309629

SPA12
Serpin A12

1

6

High-throughput

0.489

High

1322388

PGAM4
Probable phosphoglycerate mutase 4

1

1

High-throughput

0.489

High

504769

FBSP1
F-box/SPRY domain-containing protein 1

1

6

Small-scale

0.479

High

1054808

SUH
Recombining binding protein suppressor of hairless

1

1

Small-scale

0.479

High

1287461

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

1403037

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

1458599

SE1L1
Protein sel-1 homolog 1

1

1

Small-scale

0.479

High

1458600

HDAC9
Histone deacetylase 9

1

7

Small-scale

0.479

High

1458601

FBW1A
F-box/WD repeat-containing protein 1A

1

7

Small-scale

0.479

High

840093

CASP3
Caspase-3

1

0

Small-scale

0.458

High

516216

HS71B
Heat shock 70 kDa protein 1B

1

6

High-throughput

0.445

High

1428314

DERL2
Derlin-2

1

1

Small-scale

0.437

High

47595

RPSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.426

High

1388019

RSPRY
RING finger and SPRY domain-containing protein 1

1

0

High-throughput

0.426

High

70523

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1307072

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

1419141

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.316

High

892144

KLK7
Kallikrein-7

1

0

High-throughput

0.279

Low

1248747

SBSN
Suprabasin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025