HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: BCR (Q6PAJ1)
Breakpoint cluster region protein (EC 2.7.11.1)
Gene: BCR

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20697350
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2~SH2, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0019899 - enzyme binding GO:0030036 - actin cytoskeleton organization and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 1270
+	Hs
		506565 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		BCR_HUMAN (1-1270): 0: 1103: 93.56
+	Hs
		506538 FRK_HUMAN (3-202): 7.94e-39: 141: 28.84		BCR_HUMAN (1-1270): 0: 1103: 93.56
+	Hs
		924777 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		Q96D37_HUMAN (408-1089): 9.85e-85: 296: 12.50
+	Hs
		548677 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		VAV_HUMAN (408-1089): 6.07e-84: 295: 12.50
+	Mm
		654982 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		VAV_MOUSE (408-1089): 1.07e-83: 294: 13.50
+	Hs
		924563 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		ARHG7_HUMAN (276-1020): 1.09e-83: 293: 12.23
+	Hs
		924658 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		FGD6_HUMAN (286-958): 1.55e-80: 293: 16.83
+	Hs
		924525 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		ARHG5_HUMAN (96-904): 6.21e-80: 292: 14.42
+	Hs
		924870 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		ECT2_HUMAN (387-874): 8.52e-77: 275: 19.23
+	Hs
		924608 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		Q1RLN5_HUMAN (1032-1240): 1.08e-59: 223: 34.12
+	Hs
		924686 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		RHG12_HUMAN (1032-1240): 2.87e-59: 222: 34.12
+	Hs
		411580 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		VAV_HUMAN (408-1089): 6.07e-84: 295: 12.50
+	Hs
		411673 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		FGD1_HUMAN (94-1039): 3.1e-82: 292: 13.14
+	Hs
		411904 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		FARP1_HUMAN (304-844): 1.6e-77: 280: 17.11
+	Hs
		224698 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		KALRN_HUMAN (474-1086): 1.44e-61: 235: 13.18
+	Hs
		279830 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		TRIO_HUMAN (470-1016): 2.06e-55: 214: 12.80
+	Hs
		69206 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		A9UF07_HUMAN (704-938): 3.39e-28: 126: 91.06
+	Hs
		551038 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIN_HUMAN (939-1247): 1.68e-70: 246: 26.45
+	Hs
		924893 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		RHG35_HUMAN (1047-1213): 5.63e-20: 99: 31.74
+	Hs
		411755 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		RHG21_HUMAN (1048-1215): 5.9e-23: 108: 40.00