HitPredict

Interactor 1: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Interactor 2: PAXI1 (Q6ZW49)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: PAXIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	17925232, 17500065, 31076518, 24981860, 33961781, 23508102, 17178841
Identification Methods	affinity chromatography technology, biochemical, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0044666 - MLL3/4 complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 1069
+	Mm
		1240224 RBBP5_MOUSE (1-538): 2.61e-133: 399: 99.07		PAXI1_MOUSE (592-1069): 8.7e-145: 462: 92.47
+	Mm
		965392 WDR5_MOUSE (146-424): 6.36e-49: 173: 12.50		PAXI1_MOUSE (592-1069): 8.7e-145: 462: 92.47
+	Hs
		1145549 RBBP5_HUMAN (1-538): 9.43e-134: 400: 100.00		CHD7_HUMAN (188-893): 5.78e-32: 138: 8.81
+	Hs
		1257095 FBXW7_HUMAN (52-391): 4.03e-62: 218: 13.08		PAXI1_HUMAN (1-419): 3.12e-90: 314: 100.00
+	Hs
		1257125 WDR33_HUMAN (3-225): 1.03e-51: 192: 14.54		PAXI1_HUMAN (1-419): 3.12e-90: 314: 100.00
+	Hs
		965046 WDR5_HUMAN (146-424): 6.36e-49: 173: 12.50		PAXI1_HUMAN (1-419): 3.12e-90: 314: 100.00
+	Hs
		1145497 RBBP5_HUMAN (1-538): 9.43e-134: 400: 100.00		KMT2C_HUMAN (162-646): 4.44e-10: 66.6: 10.07
+	Hs
		1421315 WDR33_HUMAN (3-225): 1.03e-51: 192: 14.54		ECT2_HUMAN (26-279): 1.6e-50: 195: 14.02
+	Hs
		965250 WDR5_HUMAN (146-424): 6.36e-49: 173: 12.50		ECT2_HUMAN (26-279): 1.6e-50: 195: 14.02
+	Hs
		1380153 FBXW7_HUMAN (52-391): 4.03e-62: 218: 13.08		SIK2_HUMAN (258-632): 4.25e-25: 114: 19.26
+	Hs
		1387565 SNR40_HUMAN (229-467): 4.38e-18: 87.7: 8.56		ECT2_HUMAN (26-279): 1.6e-50: 195: 14.02
+	Hs
		1129735 WDR33_HUMAN (3-225): 1.03e-51: 192: 14.54		MDC1_HUMAN (183-870): 3.67e-10: 66.6: 7.05
+	Mm
		965395 WDR5_MOUSE (146-424): 6.36e-49: 173: 12.50		KMT2C_MOUSE (183-853): 4.41e-13: 76.2: 9.00
+	Hs
		965097 WDR5_HUMAN (146-424): 6.36e-49: 173: 12.50		KMT2C_HUMAN (162-646): 4.44e-10: 66.6: 10.07
+	Hs
		1364277 NLE1_HUMAN (2-135): 3.9e-33: 133: 18.38		TOPB1_HUMAN (3-336): 9.35e-18: 91.2: 16.57
+	Hs
		1364201 SNR40_HUMAN (229-467): 4.38e-18: 87.7: 8.56		TOPB1_HUMAN (3-336): 9.35e-18: 91.2: 16.57
+	Hs
		1129693 SNR40_HUMAN (229-467): 4.38e-18: 87.7: 8.56		MDC1_HUMAN (183-870): 3.67e-10: 66.6: 7.05