Protein: RBBP5
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)

Gene: RBBP5
Organism: Homo sapiens
Interactions: 235
UniProt ID: Q15291

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1041530

KMT2A
Histone-lysine N-methyltransferase 2A

16

20

Small-scale

0.986

High

175891

SET1A
Histone-lysine N-methyltransferase SETD1A

18

20

Small-scale

0.986

High

161472

KMT2D
Histone-lysine N-methyltransferase 2D

17

20

Small-scale

0.983

High

1145497

KMT2C
Histone-lysine N-methyltransferase 2C

11

20

Small-scale

0.978

High

1145563

SET1B
Histone-lysine N-methyltransferase SETD1B

10

20

Small-scale

0.974

High

1145562

KMT2B
Histone-lysine N-methyltransferase 2B

10

20

Small-scale

0.970

High

1145479

WDR82
WD repeat-containing protein 82

5

20

Small-scale

0.915

High

1145535

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

18

Small-scale

0.834

High

1145463

RBBP5
Retinoblastoma-binding protein 5

2

17

Small-scale

0.799

High

964963

WDR5
WD repeat-containing protein 5

38

18

Small-scale

0.770

High

1145552

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

30

18

Small-scale

0.769

High

1145547

CXXC1
CXXC-type zinc finger protein 1

15

20

Small-scale

0.761

High

1130565

NCOA6
Nuclear receptor coactivator 6

10

20

Small-scale

0.758

High

979693

H4
Histone H4

2

6

High-throughput

0.754

High

998341

H31
Histone H3.1

2

14

High-throughput

0.754

High

194567

KDM6A
Lysine-specific demethylase 6A

10

19

Small-scale

0.752

High

1145481

PAXI1
PAX-interacting protein 1

7

17

Small-scale

0.746

High

1145571

HCFC2
Host cell factor 2

7

8

Small-scale

0.741

High

1145521

DPY30
Protein dpy-30 homolog

7

5

Small-scale

0.740

High

1145498

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

6

20

High-throughput

0.729

High

905408

HCFC1
Host cell factor 1

6

8

Small-scale

0.724

High

129105

MEN1
Menin

6

5

Small-scale

0.719

High

501997

H2AZ
Histone H2A.Z

1

11

High-throughput

0.691

High

728250

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

High-throughput

0.691

High

1110996

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.691

High

1145466

DDB1
DNA damage-binding protein 1

1

10

Small-scale

0.691

High

1145469

H2B2E
Histone H2B type 2-E

1

10

High-throughput

0.691

High

1145543

MIOS
GATOR2 complex protein MIOS

1

7

High-throughput

0.691

High

185718

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

4

14

Small-scale

0.683

High

396157

ESR1
Estrogen receptor

4

20

Small-scale

0.683

High

413878

P53
Cellular tumor antigen p53

3

5

Small-scale

0.680

High

961735

RL37A
Large ribosomal subunit protein eL43

3

2

High-throughput

0.667

High

1145518

PAGR1
PAXIP1-associated glutamate-rich protein 1

3

1

Small-scale

0.662

High

1145539

MBIP1
MAP3K12-binding inhibitory protein 1

3

3

High-throughput

0.656

High

764771

CTNB1
Catenin beta-1

3

9

Small-scale

0.651

High

1145507

BOD1
Biorientation of chromosomes in cell division protein 1

3

3

High-throughput

0.650

High

1145551

RERE
Arginine-glutamic acid dipeptide repeats protein

3

15

High-throughput

0.650

High

993579

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.647

High

1145468

H31T
Histone H3.1t

1

14

Small-scale

0.647

High

1145482

H32
Histone H3.2

1

14

Small-scale

0.647

High

1145529

KAT8
Histone acetyltransferase KAT8

2

6

Small-scale

0.621

High

572927

INSRR
Insulin receptor-related protein

1

7

High-throughput

0.618

High

1145478

WDR59
GATOR2 complex protein WDR59

1

19

High-throughput

0.618

High

1145486

URP2
Fermitin family homolog 3

1

1

High-throughput

0.618

High

1145510

WDR24
GATOR2 complex protein WDR24

1

19

High-throughput

0.618

High

224295

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

257863

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

4

High-throughput

0.618

High

315609

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.618

High

419000

H2A1B
Histone H2A type 1-B/E

1

8

High-throughput

0.618

High

754853

H2B1B
Histone H2B type 1-B

1

10

High-throughput

0.618

High

926360

BLM
RecQ-like DNA helicase BLM

1

20

High-throughput

0.618

High

980785

H2B1C
Histone H2B type 1-C/E/F/G/I

1

10

High-throughput

0.618

High

1016880

H33
Histone H3.3

1

14

High-throughput

0.618

High

1127719

HLTF
Helicase-like transcription factor

1

14

High-throughput

0.618

High

1145471

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

20

High-throughput

0.618

High

1145499

NUP43
Nucleoporin Nup43

1

19

High-throughput

0.618

High

1145508

H2A1H
Histone H2A type 1-H

1

8

High-throughput

0.618

High

1145530

CSR2B
Cysteine-rich protein 2-binding protein

1

11

High-throughput

0.618

High

1145531

WDR76
WD repeat-containing protein 76

1

19

High-throughput

0.618

High

1145540

DCA13
DDB1- and CUL4-associated factor 13

1

19

High-throughput

0.618

High

1145541

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.618

High

1145542

DDX18
ATP-dependent RNA helicase DDX18

1

20

High-throughput

0.618

High

1145548

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

10

High-throughput

0.618

High

1145549

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

18

Small-scale

0.618

High

997731

CSK21
Casein kinase II subunit alpha

2

11

High-throughput

0.611

High

1065212

SSRP1
FACT complex subunit SSRP1

2

19

High-throughput

0.611

High

1145470

CYTSB
Cytospin-B

2

14

High-throughput

0.611

High

1145495

RB15B
Putative RNA-binding protein 15B

2

8

High-throughput

0.611

High

1145566

KDM2A
Lysine-specific demethylase 2A

2

11

High-throughput

0.611

High

193578

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

4

High-throughput

0.601

High

928274

ATN1
Atrophin-1

2

20

High-throughput

0.601

High

1133421

NFIX
Nuclear factor 1 X-type

2

14

High-throughput

0.601

High

789498

PPARG
Peroxisome proliferator-activated receptor gamma

2

17

Small-scale

0.594

High

455778

H10
Histone H1.0

2

0

High-throughput

0.585

High

241744

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.584

High

648360

USF1
Upstream stimulatory factor 1

2

20

Small-scale

0.584

High

872351

SOX2
Transcription factor SOX-2

2

16

Small-scale

0.584

High

1067352

EP300
Histone acetyltransferase p300

2

15

Small-scale

0.584

High

1145484

KANL1
KAT8 regulatory NSL complex subunit 1

2

4

Small-scale

0.584

High

1145503

CBP
CREB-binding protein

2

14

Small-scale

0.584

High

1145561

YETS2
YEATS domain-containing protein 2

2

20

High-throughput

0.584

High

1145475

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.575

High

1145504

FBXW7
F-box/WD repeat-containing protein 7

1

17

High-throughput

0.575

High

910914

IMA1
Importin subunit alpha-1

2

4

High-throughput

0.571

High

1126898

RBM39
RNA-binding protein 39

1

12

Small-scale

0.561

High

1145516

PYGO2
Pygopus homolog 2

1

1

Small-scale

0.561

High

1145528

ZN335
Zinc finger protein 335

1

3

Small-scale

0.554

High

157406

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.553

High

1145480

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

1145527

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.553

High

158696

UTY
Histone demethylase UTY

1

17

High-throughput

0.536

High

542036

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

571605

IRF2
Interferon regulatory factor 2

1

1

High-throughput

0.536

High

601686

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.536

High

625398

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.536

High

854071

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

885783

KC1E
Casein kinase I isoform epsilon

1

9

High-throughput

0.536

High

916660

PPP5
Serine/threonine-protein phosphatase 5

1

5

High-throughput

0.536

High

945668

SESN2
Sestrin-2

1

1

High-throughput

0.536

High

995048

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

1013062

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

4

High-throughput

0.536

High

1029683

FOXK2
Forkhead box protein K2

1

4

High-throughput

0.536

High

1114833

CUL4A
Cullin-4A

1

20

Small-scale

0.536

High

1115201

CUL4B
Cullin-4B

1

20

Small-scale

0.536

High

1134590

NUMA1
Nuclear mitotic apparatus protein 1

1

17

High-throughput

0.536

High

1145485

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

Small-scale

0.536

High

1145502

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

15

High-throughput

0.536

High

1145512

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

1145515

ASCL2
Achaete-scute homolog 2

1

2

Small-scale

0.536

High

1145522

FOXQ1
Forkhead box protein Q1

1

4

High-throughput

0.536

High

1145524

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1145536

E41L5
Band 4.1-like protein 5

1

4

High-throughput

0.536

High

1145556

TBK1
Serine/threonine-protein kinase TBK1

1

8

High-throughput

0.536

High

474003

NFIC
Nuclear factor 1 C-type

1

14

High-throughput

0.515

High

1145477

CDC73
Parafibromin

1

0

Small-scale

0.513

High

1103177

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.508

High

442722

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.501

High

951685

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

67550

MYH7B
Myosin-7B

1

3

High-throughput

0.489

High

1145491

MICU2
Calcium uptake protein 2, mitochondrial

1

2

High-throughput

0.489

High

1145538

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.489

High

143007

NFIB
Nuclear factor 1 B-type

1

5

High-throughput

0.479

High

144265

ACACB
Acetyl-CoA carboxylase 2

1

13

High-throughput

0.479

High

154697

ARI1A
AT-rich interactive domain-containing protein 1A

1

18

High-throughput

0.479

High

176066

KDM6B
Lysine-specific demethylase 6B

1

20

Small-scale

0.479

High

181514

TBXT
T-box transcription factor T

1

4

High-throughput

0.479

High

210001

CRX
Cone-rod homeobox protein

1

7

High-throughput

0.479

High

252246

CCNT2
Cyclin-T2

1

3

High-throughput

0.479

High

259984

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

283099

PSIP1
PC4 and SFRS1-interacting protein

1

11

High-throughput

0.479

High

322660

KDM4B
Lysine-specific demethylase 4B

1

5

Small-scale

0.479

High

370675

FOS
Protein c-Fos

1

6

High-throughput

0.479

High

372085

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

444985

S10A9
Protein S100-A9

1

3

High-throughput

0.479

High

519377

MYB
Transcriptional activator Myb

1

8

Small-scale

0.479

High

520066

ANDR
Androgen receptor

1

18

High-throughput

0.479

High

521700

H14
Histone H1.4

1

11

High-throughput

0.479

High

528259

THIO
Thioredoxin

1

8

High-throughput

0.479

High

538397

EGR2
E3 SUMO-protein ligase EGR2

1

3

High-throughput

0.479

High

542525

TOP2A
DNA topoisomerase 2-alpha

1

7

High-throughput

0.479

High

581660

MYOD1
Myoblast determination protein 1

1

2

High-throughput

0.479

High

587671

DESP
Desmoplakin

1

20

High-throughput

0.479

High

637527

FLNA
Filamin-A

1

15

High-throughput

0.479

High

662427

GATA2
Endothelial transcription factor GATA-2

1

6

High-throughput

0.479

High

675508

TYY1
Transcriptional repressor protein YY1

1

6

High-throughput

0.479

High

681380

PSA3
Proteasome subunit alpha type-3

1

5

Small-scale

0.479

High

685199

PAX6
Paired box protein Pax-6

1

5

High-throughput

0.479

High

686174

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.479

High

718571

CDC27
Cell division cycle protein 27 homolog

1

8

Small-scale

0.479

High

738983

ELF1
ETS-related transcription factor Elf-1

1

12

High-throughput

0.479

High

775843

HNF1B
Hepatocyte nuclear factor 1-beta

1

9

High-throughput

0.479

High

799137

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.479

High

824160

RL13A
Large ribosomal subunit protein uL13

1

5

High-throughput

0.479

High

833945

HNF4A
Hepatocyte nuclear factor 4-alpha

1

14

High-throughput

0.479

High

837046

ELK3
ETS domain-containing protein Elk-3

1

11

High-throughput

0.479

High

842652

WASP
Actin nucleation-promoting factor WAS

1

8

Small-scale

0.479

High

895717

LHX2
LIM/homeobox protein Lhx2

1

1

High-throughput

0.479

High

904745

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

944656

KLF3
Krueppel-like factor 3

1

13

High-throughput

0.479

High

982958

RS25
Small ribosomal subunit protein eS25

1

3

High-throughput

0.479

High

1014518

SMAD3
Mothers against decapentaplegic homolog 3

1

3

Small-scale

0.479

High

1029839

RUNX1
Runt-related transcription factor 1

1

2

High-throughput

0.479

High

1037160

H11
Histone H1.1

1

11

High-throughput

0.479

High

1056608

PAX8
Paired box protein Pax-8

1

5

High-throughput

0.479

High

1087750

NFIA
Nuclear factor 1 A-type

1

12

High-throughput

0.479

High

1099918

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

1103045

PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

1

4

High-throughput

0.479

High

1105019

TCOF
Treacle protein

1

20

High-throughput

0.479

High

1106898

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1113160

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1117557

NOG2
Nucleolar GTP-binding protein 2

1

10

High-throughput

0.479

High

1118708

KLF5
Krueppel-like factor 5

1

12

High-throughput

0.479

High

1132605

KIF22
Kinesin-like protein KIF22

1

4

High-throughput

0.479

High

1139914

RRS1
Ribosome biogenesis regulatory protein homolog

1

3

High-throughput

0.479

High

1145464

ELF2
ETS-related transcription factor Elf-2

1

10

High-throughput

0.479

High

1145465

SMAD2
Mothers against decapentaplegic homolog 2

1

3

Small-scale

0.479

High

1145467

TBR1
T-box brain protein 1

1

4

High-throughput

0.479

High

1145474

MAP1S
Microtubule-associated protein 1S

1

9

High-throughput

0.479

High

1145476

IFIX
Pyrin and HIN domain-containing protein 1

1

7

High-throughput

0.479

High

1145488

P66A
Transcriptional repressor p66-alpha

1

2

High-throughput

0.479

High

1145489

TF2LX
Homeobox protein TGIF2LX

1

4

High-throughput

0.479

High

1145490

ZZZ3
ZZ-type zinc finger-containing protein 3

1

2

High-throughput

0.479

High

1145492

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

Small-scale

0.479

High

1145493

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

1145494

Z280C
Zinc finger protein 280C

1

7

High-throughput

0.479

High

1145496

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

18

Small-scale

0.479

High

1145500

MAFA
Transcription factor MafA

1

7

Small-scale

0.479

High

1145501

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1145506

MCRS1
Microspherule protein 1

1

2

High-throughput

0.479

High

1145509

ZN512
Zinc finger protein 512

1

2

High-throughput

0.479

High

1145511

MINT
Msx2-interacting protein

1

18

High-throughput

0.479

High

1145513

ELF4
ETS-related transcription factor Elf-4

1

11

High-throughput

0.479

High

1145514

PRP18
Pre-mRNA-splicing factor 18

1

1

High-throughput

0.479

High

1145517

GPTC1
G patch domain-containing protein 1

1

7

High-throughput

0.479

High

1145519

PAPOG
Poly(A) polymerase gamma

1

2

High-throughput

0.479

High

1145520

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

12

High-throughput

0.479

High

1145523

NAT10
RNA cytidine acetyltransferase

1

2

Small-scale

0.479

High

1145525

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

8

Small-scale

0.479

High

1145526

SENP3
Sentrin-specific protease 3

1

7

Small-scale

0.479

High

1145532

KANL2
KAT8 regulatory NSL complex subunit 2

1

2

High-throughput

0.479

High

1145533

NANOG
Homeobox protein NANOG

1

10

High-throughput

0.479

High

1145534

ZN532
Zinc finger protein 532

1

2

High-throughput

0.479

High

1145537

INCE
Inner centromere protein

1

16

High-throughput

0.479

High

1145545

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1145550

KANL3
KAT8 regulatory NSL complex subunit 3

1

3

High-throughput

0.479

High

1145553

LHX3
LIM/homeobox protein Lhx3

1

1

High-throughput

0.479

High

1145554

POLK
DNA polymerase kappa

1

1

High-throughput

0.479

High

1145555

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1145557

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

20

High-throughput

0.479

High

1145559

AGO2
Protein argonaute-2

1

3

Small-scale

0.479

High

1145560

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.479

High

1145564

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.479

High

1145567

NOP58
Nucleolar protein 58

1

7

High-throughput

0.479

High

1145568

KDM3A
Lysine-specific demethylase 3A

1

3

High-throughput

0.479

High

1145569

SP16H
FACT complex subunit SPT16

1

6

High-throughput

0.479

High

1145570

MAFB
Transcription factor MafB

1

13

Small-scale

0.479

High

1145572

MORC2
ATPase MORC2

1

2

High-throughput

0.479

High

703144

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

1125813

FRG1
Protein FRG1

1

0

High-throughput

0.458

High

1132657

MEF2D
Myocyte-specific enhancer factor 2D

1

0

Small-scale

0.458

High

1145483

TBA1A
Tubulin alpha-1A chain

1

16

Small-scale

0.445

High

1145487

WDR5B
WD repeat-containing protein 5B

1

19

Small-scale

0.445

High

1145544

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.445

High

1145546

GRHL1
Grainyhead-like protein 1 homolog

1

3

High-throughput

0.445

High

345855

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

13

High-throughput

0.437

High

428405

RLA2
Large ribosomal subunit protein P2

1

2

High-throughput

0.437

High

923699

SMTN
Smoothelin

1

10

High-throughput

0.437

High

1145472

KPRP
Keratinocyte proline-rich protein

1

2

High-throughput

0.437

High

1145473

RN123
E3 ubiquitin-protein ligase RNF123

1

12

High-throughput

0.437

High

1145505

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.279

Low

1083511

BST2
Bone marrow stromal antigen 2

1

0

High-throughput

0.269

Low

942002

NDK5
Nucleoside diphosphate kinase homolog 5

1

0

High-throughput

0.232

Low

1145558

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.232

Low

1145565

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025