HitPredict

Interactor 1: K1H1 (Q15323)
Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1) (Keratin-31) (K31)
Gene: KRT31

Interactor 2: TRAF4 (Q9BUZ4)
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
Gene: TRAF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 470
+	Hs
		300691 KRT37_HUMAN (17-409): 1.92e-148: 430: 60.91		TRAF4_HUMAN (1-470): 1.68e-126: 377: 100.00
+	Hs
		1230233 K1C40_HUMAN (6-385): 2.33e-143: 416: 62.69		TRAF4_HUMAN (1-470): 1.68e-126: 377: 100.00
+	Hs
		323071 K1C14_HUMAN (54-367): 6.74e-142: 414: 61.15		TRI37_HUMAN (5-465): 9.12e-63: 221: 12.92
+	Hs
		323116 K1C19_HUMAN (48-366): 8.95e-141: 409: 56.11		TRI37_HUMAN (5-465): 9.12e-63: 221: 12.92
+	Mm
		1221518 KRT87_MOUSE (4-415): 8.21e-99: 305: 24.48		TRAF3_MOUSE (3-465): 2.35e-98: 308: 24.17
+	Mm
		1221547 KRT81_MOUSE (4-415): 4.1e-99: 305: 25.77		TRAF3_MOUSE (3-465): 2.35e-98: 308: 24.17
+	Mm
		1022002 KRT86_MOUSE (4-404): 6.43e-98: 302: 24.76		TRAF3_MOUSE (3-465): 2.35e-98: 308: 24.17
+	Hs
		1404321 K1C12_HUMAN (50-363): 1.86e-103: 317: 54.40		TRAF6_HUMAN (3-464): 2.86e-90: 285: 25.21
+	Mm
		72997 KRT36_MOUSE (4-410): 1.89e-94: 293: 66.75		TRAF3_MOUSE (3-465): 2.35e-98: 308: 24.17
+	Hs
		566232 K1C10_HUMAN (52-361): 3.2e-95: 298: 56.01		TRAF6_HUMAN (3-464): 2.86e-90: 285: 25.21
+	Hs
		300753 KRT38_HUMAN (11-413): 1.22e-92: 288: 60.89		TRAF3_HUMAN (3-465): 6.94e-90: 286: 22.99
+	Hs
		585054 K1C40_HUMAN (6-385): 2.33e-143: 416: 62.69		ZN250_HUMAN (5-218): 7.81e-41: 155: 15.68
+	Hs
		341764 K2C75_HUMAN (19-381): 5.07e-95: 297: 26.58		TRAF1_HUMAN (16-465): 1.78e-69: 229: 23.97
+	Hs
		323143 K1C10_HUMAN (52-361): 3.2e-95: 298: 56.01		TRI37_HUMAN (5-465): 9.12e-63: 221: 12.92
+	Hs
		1230098 K1C40_HUMAN (6-385): 2.33e-143: 416: 62.69		ZFP2_HUMAN (4-161): 5.76e-21: 97.2: 10.76
+	Hs
		300707 KRT38_HUMAN (11-413): 1.22e-92: 288: 60.89		TRI37_HUMAN (5-465): 9.12e-63: 221: 12.92
+	Hs
		623294 K1C17_HUMAN (49-367): 1.14e-116: 348: 59.88		RO52_HUMAN (9-268): 4.48e-43: 160: 15.33
+	Hs
		323082 K2C6B_HUMAN (19-391): 1.08e-84: 270: 24.00		TRI37_HUMAN (5-465): 9.12e-63: 221: 12.92
+	Hs
		585035 K1H1_HUMAN (1-416): 2.67e-90: 280: 100.00		ZN250_HUMAN (5-218): 7.81e-41: 155: 15.68
+	Hs
		300363 KRT34_HUMAN (1-391): 2.98e-95: 292: 89.00		ZNF79_HUMAN (240-353): 3.37e-09: 61: 7.30