HitPredict

Interactor 1: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Interactor 2: UBE3B (Q7Z3V4)
Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)
Gene: UBE3B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	37783786
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 145 Hs			1 1068
+	Hs
		906670 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		UBE3C_HUMAN (6-1068): 0: 579: 25.55
+	Hs
		982191 UB2D2_HUMAN (10-144): 2.48e-58: 179: 22.06		UBE3C_HUMAN (6-1068): 0: 579: 25.55
+	Hs
		861524 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		NEDD4_HUMAN (604-1066): 1.86e-158: 505: 28.54
+	Hs
		1394641 UB2D4_HUMAN (10-144): 7.14e-60: 183: 24.27		ITCH_HUMAN (604-1066): 1.36e-161: 502: 28.02
+	Hs
		861552 UB2D2_HUMAN (10-144): 2.48e-58: 179: 22.06		NEDD4_HUMAN (604-1066): 1.86e-158: 505: 28.54
+	Hs
		906748 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		ITCH_HUMAN (604-1066): 1.36e-161: 502: 28.02
+	Hs
		906753 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		NED4L_HUMAN (604-1066): 8.59e-159: 497: 27.68
+	Hs
		132395 UB2D4_HUMAN (10-144): 7.14e-60: 183: 24.27		WWP2_HUMAN (655-1066): 6.27e-159: 494: 29.30
+	Hs
		131839 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		WWP2_HUMAN (655-1066): 6.27e-159: 494: 29.30
+	Hs
		131913 UB2D2_HUMAN (10-144): 2.48e-58: 179: 22.06		WWP2_HUMAN (655-1066): 6.27e-159: 494: 29.30
+	Sc
		815511 MMS2_YEAST (8-143): 4.95e-63: 190: 50.00		RSP5_YEAST (604-1066): 8.15e-154: 479: 27.31
+	Hs
		906781 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		WWP1_HUMAN (615-1066): 2.41e-153: 481: 26.71
+	Hs
		906689 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		HUWE1_HUMAN (608-1068): 7.3e-141: 471: 30.02
+	Sp
		153856 UBC4_SCHPO (10-144): 1.27e-58: 180: 23.53		PUB3_SCHPO (592-1066): 2.5e-151: 471: 27.25
+	Hs
		906789 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		SMUF1_HUMAN (641-1065): 1.04e-150: 469: 27.64
+	Hs
		906788 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		SMUF2_HUMAN (646-1065): 1.31e-150: 468: 27.25
+	Hs
		982224 UB2D2_HUMAN (10-144): 2.48e-58: 179: 22.06		HUWE1_HUMAN (608-1068): 7.3e-141: 471: 30.02
+	Hs
		982241 UB2D2_HUMAN (10-144): 2.48e-58: 179: 22.06		HACE1_HUMAN (622-1063): 2.03e-142: 452: 28.54
+	Hs
		906687 UB2D1_HUMAN (10-145): 1.75e-59: 182: 24.82		HECW1_HUMAN (678-1067): 4.14e-46: 183: 33.08
+	Hs
		982221 UB2D2_HUMAN (10-144): 2.48e-58: 179: 22.06		HECW1_HUMAN (678-1067): 4.14e-46: 183: 33.08