HitPredict

Interactor 1: NEDD8 (Q15843)
Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8)
Gene: NEDD8

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	28169289
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 748
+	Hs
		987478 RL40_HUMAN (1-76): 3.81e-33: 112: 57.90		SMUF2_HUMAN (1-748): 0: 837: 100.00
+	Hs
		507377 UBB_HUMAN (1-76): 2.41e-30: 107: 57.90		SMUF2_HUMAN (1-748): 0: 837: 100.00
+	Hs
		1154937 NEDD8_HUMAN (1-81): 2.08e-30: 103: 100.00		SMUF1_HUMAN (1-748): 0: 753: 70.31
+	Sp
		153855 RL402_SCHPO (1-76): 6.91e-32: 109: 55.26		PUB3_SCHPO (10-748): 0: 662: 34.64
+	Sp
		153853 RS27A_SCHPO (1-71): 1.02e-29: 104: 53.52		PUB3_SCHPO (10-748): 0: 662: 34.64
+	Sp
		153854 RS27B_SCHPO (1-71): 8.49e-30: 104: 53.52		PUB3_SCHPO (10-748): 0: 662: 34.64
+	Sc
		436424 RS31_YEAST (1-70): 3.05e-30: 105: 52.86		RSP5_YEAST (11-748): 0: 634: 34.45
+	Sc
		815560 RUB1_YEAST (1-76): 1.46e-21: 81.3: 59.21		RSP5_YEAST (11-748): 0: 634: 34.45
+	Mm
		987293 RS27A_MOUSE (1-77): 8.69e-37: 122: 57.14		HUWE1_MOUSE (151-747): 0: 587: 33.22
+	Hs
		987397 RL40_HUMAN (1-76): 3.81e-33: 112: 57.90		HUWE1_HUMAN (114-747): 0: 591: 31.46
+	Hs
		507253 UBB_HUMAN (1-76): 2.41e-30: 107: 57.90		HUWE1_HUMAN (114-747): 0: 591: 31.46
+	Sc
		509922 RL40A_YEAST (1-76): 1.88e-32: 110: 55.26		TOM1_YEAST (325-747): 1.65e-164: 528: 40.47
+	Sc
		436502 RS31_YEAST (1-70): 3.05e-30: 105: 52.86		TOM1_YEAST (325-747): 1.65e-164: 528: 40.47
+	Dm
		94226 RL40_DROME (1-76): 1.77e-33: 112: 57.90		D5SHR3_DROME (343-748): 1.97e-165: 485: 42.48
+	Hs
		131925 RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14		WWP2_HUMAN (1-416): 3.08e-25: 114: 15.94
+	Hs
		987205 RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14		WWP1_HUMAN (2-430): 3.39e-22: 104: 13.94
+	Hs
		507318 UBB_HUMAN (1-76): 2.41e-30: 107: 57.90		ITCH_HUMAN (1-426): 1.04e-26: 118: 17.13
+	Hs
		131689 UBB_HUMAN (1-76): 2.41e-30: 107: 57.90		WWP2_HUMAN (1-416): 3.08e-25: 114: 15.94
+	Hs
		507111 UBB_HUMAN (1-76): 2.41e-30: 107: 57.90		NEDD4_HUMAN (88-375): 9.05e-14: 77.5: 16.67