HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: H2B1H (Q93079)
Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)
Gene: H2BC9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~preSET_CXC, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 126
+	Hs
		1155420 EZH2_HUMAN (1-746): 0: 864: 100.00		H2B2E_HUMAN (1-126): 5.76e-55: 169: 98.41
+	Hs
		256868 EZH2_HUMAN (1-746): 0: 864: 100.00		H2B1K_HUMAN (1-126): 1.19e-54: 168: 98.41
+	Hs
		980794 EZH2_HUMAN (1-746): 0: 864: 100.00		H2B1C_HUMAN (1-126): 1.08e-54: 168: 99.21
+	Hs
		355536 NSD2_HUMAN (275-729): 1.3e-91: 314: 16.03		H2B2E_HUMAN (1-126): 5.76e-55: 169: 98.41
+	Hs
		355476 NSD2_HUMAN (275-729): 1.3e-91: 314: 16.03		H2B1C_HUMAN (1-126): 1.08e-54: 168: 99.21
+	Hs
		1163142 NSD1_HUMAN (275-729): 2.84e-90: 312: 15.82		H2B2E_HUMAN (1-126): 5.76e-55: 169: 98.41
+	Hs
		1372270 NSD1_HUMAN (275-729): 2.84e-90: 312: 15.82		H2B1H_HUMAN (1-126): 4.33e-55: 169: 100.00
+	Hs
		981018 NSD1_HUMAN (275-729): 2.84e-90: 312: 15.82		H2B1C_HUMAN (1-126): 1.08e-54: 168: 99.21
+	Hs
		1372315 ASH1L_HUMAN (356-733): 8.9e-72: 257: 20.66		H2B1H_HUMAN (1-126): 4.33e-55: 169: 100.00
+	Sc
		381513 SET1_YEAST (205-733): 1.2e-84: 291: 16.01		H2B2_YEAST (3-125): 4.17e-41: 134: 71.55
+	Hs
		1163213 EHMT1_HUMAN (441-732): 1.63e-70: 253: 24.27		H2B2E_HUMAN (1-126): 5.76e-55: 169: 98.41
+	Hs
		981106 EHMT1_HUMAN (441-732): 1.63e-70: 253: 24.27		H2B1C_HUMAN (1-126): 1.08e-54: 168: 99.21
+	Hs
		1163187 NSD3_HUMAN (275-729): 8.3e-70: 251: 14.42		H2B2E_HUMAN (1-126): 5.76e-55: 169: 98.41
+	Hs
		754975 NSD3_HUMAN (275-729): 8.3e-70: 251: 14.42		H2B1B_HUMAN (1-126): 1.45e-54: 168: 96.83
+	Hs
		981070 NSD3_HUMAN (275-729): 8.3e-70: 251: 14.42		H2B1C_HUMAN (1-126): 1.08e-54: 168: 99.21
+	Hs
		1163141 EHMT2_HUMAN (467-732): 1.85e-68: 247: 24.21		H2B2E_HUMAN (1-126): 5.76e-55: 169: 98.41
+	Hs
		981017 EHMT2_HUMAN (467-732): 1.85e-68: 247: 24.21		H2B1C_HUMAN (1-126): 1.08e-54: 168: 99.21
+	Sp
		237890 CLR4_SCHPO (330-726): 9.57e-80: 265: 19.09		H2B1_SCHPO (4-125): 6.08e-46: 146: 70.49
+	Hs
		1323957 EHMT2_HUMAN (467-732): 1.85e-68: 247: 24.21		H2B3B_HUMAN (1-126): 1.46e-52: 163: 96.03
+	Hs
		1381865 EHMT1_HUMAN (441-732): 1.63e-70: 253: 24.27		H2B1A_HUMAN (1-126): 1.15e-47: 151: 84.25