HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PHD, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 126
+	Hs
		355536 NSD2_HUMAN (1-1365): 0: 988: 100.00		H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21
+	Hs
		1163187 NSD3_HUMAN (116-1340): 0: 764: 45.27		H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21
+	Hs
		981070 NSD3_HUMAN (116-1340): 0: 764: 45.27		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		754975 NSD3_HUMAN (116-1340): 0: 764: 45.27		H2B1B_HUMAN (1-126): 1.53e-53: 165: 97.62
+	Hs
		216353 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H2B1K_HUMAN (1-126): 1.31e-53: 166: 99.21
+	Hs
		1372315 ASH1L_HUMAN (924-1232): 1.68e-58: 225: 31.75		H2B1H_HUMAN (1-126): 5.52e-54: 166: 99.21
+	Hs
		1155420 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21
+	Hs
		1155631 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		H2B1H_HUMAN (1-126): 5.52e-54: 166: 99.21
+	Hs
		256868 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		H2B1K_HUMAN (1-126): 1.31e-53: 166: 99.21
+	Hs
		980794 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		1163213 EHMT1_HUMAN (906-1224): 5.89e-56: 215: 21.43		H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21
+	Hs
		981106 EHMT1_HUMAN (906-1224): 5.89e-56: 215: 21.43		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		1163141 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21
+	Hs
		981017 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		1323957 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		H2B3B_HUMAN (1-126): 8.33e-52: 161: 95.24
+	Hs
		1381865 EHMT1_HUMAN (906-1224): 5.89e-56: 215: 21.43		H2B1A_HUMAN (1-126): 3.15e-46: 147: 84.25
+	Sp
		237890 CLR4_SCHPO (947-1202): 5.07e-59: 214: 23.10		H2B1_SCHPO (4-125): 1.06e-45: 146: 70.49
+	Hs
		1381843 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		H2B1A_HUMAN (1-126): 3.15e-46: 147: 84.25
+	Sc
		381513 SET1_YEAST (995-1203): 5.02e-62: 233: 31.11		H2B2_YEAST (3-125): 5.54e-37: 124: 71.55
+	Hs
		256839 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		H2B1K_HUMAN (1-126): 1.31e-53: 166: 99.21