HitPredict

Interactor 1: Q24253 (Q24253)
AP complex subunit beta
Gene: AP-1-2beta

Interactor 2: Q9VDC3 (Q9VDC3)
AP complex subunit sigma
Gene: AP-2sigma

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0030122 - AP-2 adaptor complex GO:0035615 - clathrin adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 921 Dm			1 142
+	Hs
		965407 AP2B1_HUMAN (1-920): 0: 840: 72.07		AP1S1_HUMAN (1-142): 1.96e-51: 162: 45.07
+	Hs
		940551 AP2B1_HUMAN (1-920): 0: 840: 72.07		AP1S2_HUMAN (2-142): 4.12e-51: 161: 46.81
+	Hs
		989084 AP2B1_HUMAN (1-920): 0: 840: 72.07		AP1S3_HUMAN (1-142): 1.18e-49: 157: 43.66
+	Dm
		264397 Q24253_DROME (1-921): 0: 850: 100.00		O62530_DROME (1-138): 2.33e-42: 146: 16.67
+	Hs
		965408 AP1B1_HUMAN (1-920): 0: 833: 72.21		AP1S1_HUMAN (1-142): 1.96e-51: 162: 45.07
+	Hs
		940552 AP1B1_HUMAN (1-920): 0: 833: 72.21		AP1S2_HUMAN (2-142): 4.12e-51: 161: 46.81
+	Hs
		989100 AP2B1_HUMAN (1-920): 0: 840: 72.07		AP1M1_HUMAN (2-137): 3.53e-44: 151: 14.71
+	Hs
		989182 AP2B1_HUMAN (1-920): 0: 840: 72.07		AP1M2_HUMAN (2-142): 2.74e-44: 151: 20.14
+	Hs
		1083296 AP1B1_HUMAN (1-920): 0: 833: 72.21		AP1S3_HUMAN (1-142): 1.18e-49: 157: 43.66
+	Hs
		922564 AP2B1_HUMAN (1-920): 0: 840: 72.07		AP2S1_HUMAN (1-142): 4.87e-46: 148: 95.78
+	Hs
		1083305 AP1B1_HUMAN (1-920): 0: 833: 72.21		AP1M1_HUMAN (2-137): 3.53e-44: 151: 14.71
+	Hs
		1083343 AP1B1_HUMAN (1-920): 0: 833: 72.21		AP1M2_HUMAN (2-142): 2.74e-44: 151: 20.14
+	Hs
		989075 AP2B1_HUMAN (1-920): 0: 840: 72.07		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Hs
		922570 AP1B1_HUMAN (1-920): 0: 833: 72.21		AP2S1_HUMAN (1-142): 4.87e-46: 148: 95.78
+	Hs
		1083291 AP1B1_HUMAN (1-920): 0: 833: 72.21		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Ce
		773424 Q9N4F3_CAEEL (1-918): 0: 757: 66.70		AP2M_CAEEL (1-138): 1.9e-43: 149: 15.94
+	Ce
		773416 Q9N4F3_CAEEL (1-918): 0: 757: 66.70		AP1M_CAEEL (3-137): 9.11e-43: 147: 20.00
+	At
		1285103 APBLB_ARATH (3-920): 0: 759: 57.44		AP2S_ARATH (1-142): 1.24e-44: 144: 59.86
+	Zm
		30164 A0A1D6K3D9_MAIZE (41-919): 0: 723: 56.17		Q9MAY9_MAIZE (2-136): 3.5e-42: 139: 17.99
+	Hs
		344658 AP2A1_HUMAN (11-916): 0: 649: 16.24		AP2S1_HUMAN (1-142): 4.87e-46: 148: 95.78