HitPredict

Interactor 1: AP2A1 (O95782)
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
Gene: AP2A1

Interactor 2: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.934

The method score is based on:

Property Details
Experiments 28514442, 31353312, 33961781, 35271311, unassigned3799
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Adaptin_N~Clat_adaptor_s
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006886 - intracellular protein transport
GO:0009898 - cytoplasmic side of plasma membrane
GO:0016192 - vesicle-mediated transport
and 9 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 977
Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025