Protein: AP1S1
AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin)

Gene: AP1S1
Organism: Homo sapiens
Interactions: 47
UniProt ID: P61966

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

225794

AP1G1
AP-1 complex subunit gamma-1

6

20

Small-scale

0.932

High

965420

AP2M1
AP-2 complex subunit mu

3

19

High-throughput

0.861

High

965429

AP1M2
AP-1 complex subunit mu-2

3

19

High-throughput

0.861

High

965407

AP2B1
AP-2 complex subunit beta

1

20

High-throughput

0.691

High

965408

AP1B1
AP-1 complex subunit beta-1

1

20

High-throughput

0.691

High

295732

AP1G2
AP-1 complex subunit gamma-like 2

1

20

Small-scale

0.621

High

940550

AP1S2
AP-1 complex subunit sigma-2

1

15

High-throughput

0.618

High

965423

AP1M1
AP-1 complex subunit mu-1

1

19

High-throughput

0.618

High

965424

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

391219

FRIL
Ferritin light chain

2

1

High-throughput

0.601

High

363079

EGFR
Epidermal growth factor receptor

2

15

High-throughput

0.584

High

483061

CLCA
Clathrin light chain A

1

7

High-throughput

0.536

High

642219

COMT
Catechol O-methyltransferase

1

3

High-throughput

0.536

High

698556

CALX
Calnexin

1

2

High-throughput

0.536

High

965422

SPT33
Spermatogenesis-associated protein 33

1

2

High-throughput

0.536

High

965425

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.536

High

925509

MOT1
Monocarboxylate transporter 1

1

1

High-throughput

0.515

High

593740

PECA1
Platelet endothelial cell adhesion molecule

1

4

High-throughput

0.515

High

788886

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.515

High

965416

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.501

High

956704

RAB10
Ras-related protein Rab-10

1

0

High-throughput

0.493

High

963040

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

High-throughput

0.493

High

965413

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.493

High

172648

XPO1
Exportin-1

1

15

High-throughput

0.479

High

941768

ARL4C
ADP-ribosylation factor-like protein 4C

1

11

High-throughput

0.479

High

965411

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

965417

ATG9A
Autophagy-related protein 9A

1

7

High-throughput

0.479

High

965409

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

1

High-throughput

0.445

High

965410

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.445

High

965427

SL9A8
Sodium/hydrogen exchanger 8

1

3

High-throughput

0.445

High

259721

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

588381

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

695114

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

767871

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

878882

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

965412

E2F4
Transcription factor E2F4

1

3

High-throughput

0.437

High

965415

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

965418

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

679323

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.426

High

965426

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.426

High

449599

KLK1
Kallikrein-1

1

4

High-throughput

0.407

High

848470

MAGA8
Melanoma-associated antigen 8

1

2

High-throughput

0.407

High

886044

CXCR3
C-X-C chemokine receptor type 3

1

4

High-throughput

0.407

High

965421

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

965428

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

965414

EBLN2
Endogenous Bornavirus-like nucleoprotein 2

1

0

High-throughput

0.269

Low

965419

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025