Protein: AP1S2
AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)

Gene: AP1S2
Organism: Homo sapiens
Interactions: 54
UniProt ID: P56377

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

225791

AP1G1
AP-1 complex subunit gamma-1

7

20

Small-scale

0.972

High

295730

AP1G2
AP-1 complex subunit gamma-like 2

4

20

Small-scale

0.905

High

940571

AP1M1
AP-1 complex subunit mu-1

4

20

High-throughput

0.903

High

940551

AP2B1
AP-2 complex subunit beta

3

20

High-throughput

0.871

High

940552

AP1B1
AP-1 complex subunit beta-1

3

20

High-throughput

0.871

High

940566

AP2M1
AP-2 complex subunit mu

3

20

High-throughput

0.861

High

940580

AP1M2
AP-1 complex subunit mu-2

3

20

High-throughput

0.861

High

940554

EPN4
Clathrin interactor 1

3

5

High-throughput

0.675

High

940556

AP1AR
AP-1 complex-associated regulatory protein

3

1

High-throughput

0.675

High

940560

AFTIN
Aftiphilin

3

1

High-throughput

0.675

High

940573

HTR5B
HEAT repeat-containing protein 5B

3

5

High-throughput

0.675

High

940575

SYNRG
Synergin gamma

3

1

High-throughput

0.675

High

940558

AAGAB
Alpha- and gamma-adaptin-binding protein p34

3

2

High-throughput

0.667

High

220485

RNF13
E3 ubiquitin-protein ligase RNF13

2

4

High-throughput

0.628

High

273659

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

8

High-throughput

0.628

High

940574

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

1

High-throughput

0.628

High

940576

STX8
Syntaxin-8

2

4

High-throughput

0.628

High

940550

AP1S1
AP-1 complex subunit sigma-1A

1

15

High-throughput

0.618

High

940548

CAV3
Caveolin-3

2

0

High-throughput

0.602

High

940579

MB212
Protein mab-21-like 2

2

3

High-throughput

0.553

High

483059

CLCA
Clathrin light chain A

1

7

High-throughput

0.536

High

642214

COMT
Catechol O-methyltransferase

1

3

High-throughput

0.536

High

938193

SEC13
Protein SEC13 homolog

1

3

High-throughput

0.536

High

940549

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.536

High

940561

NBEL1
Neurobeachin-like protein 1

1

1

High-throughput

0.536

High

940567

SPT33
Spermatogenesis-associated protein 33

1

2

High-throughput

0.536

High

940578

NOP58
Nucleolar protein 58

1

2

High-throughput

0.536

High

940557

TENS2
Tensin-2

2

3

High-throughput

0.526

High

352699

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

852647

ABCG1
ATP-binding cassette sub-family G member 1

1

0

High-throughput

0.513

High

940570

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.513

High

49156

POTB3
POTE ankyrin domain family member B3

2

5

High-throughput

0.504

High

484459

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

4

High-throughput

0.489

High

725594

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

1

High-throughput

0.489

High

940559

POTEG
POTE ankyrin domain family member G

1

3

High-throughput

0.489

High

940568

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

1

High-throughput

0.489

High

172626

XPO1
Exportin-1

1

16

High-throughput

0.479

High

241225

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

324682

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

363047

EGFR
Epidermal growth factor receptor

1

12

High-throughput

0.479

High

940563

ATG9A
Autophagy-related protein 9A

1

7

High-throughput

0.479

High

940565

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

940572

DCA13
DDB1- and CUL4-associated factor 13

1

3

Small-scale

0.479

High

529445

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

934341

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.445

High

940555

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

940577

SL9A8
Sodium/hydrogen exchanger 8

1

3

High-throughput

0.445

High

940553

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.437

High

940562

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

940564

S43A3
Equilibrative nucleobase transporter 1

1

1

High-throughput

0.437

High

97272

E9PS74
Solute carrier family 43 member 3

1

1

High-throughput

0.407

High

940569

CCM2
Cerebral cavernous malformations 2 protein

2

0

High-throughput

0.328

High

127818

CORT
Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17]

1

0

High-throughput

0.279

Low

800204

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025