HitPredict

Interactor 1: PSA2 (Q27488)
Proteasome subunit alpha type-2 (Proteasome subunit alpha 2)
Gene: pas-2

Interactor 2: PSA7 (Q95005)
Proteasome subunit alpha type-7 (Proteasome subunit alpha 4)
Gene: pas-4

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	12679813, 14704431, 11559592, 18692475, unassigned701
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019773 - proteasome core complex, alpha-subunit complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 231 Ce			1 253
+	Dm
		821867 PSA2_DROME (2-231): 4.06e-109: 314: 60.52		PSA5_DROME (2-237): 3.17e-95: 280: 32.92
+	Hs
		165303 PSA6_HUMAN (2-231): 5.68e-102: 297: 32.77		PSA7_HUMAN (1-234): 4.26e-99: 290: 63.25
+	Dm
		652725 PSA2_DROME (2-231): 4.06e-109: 314: 60.52		PSA71_DROME (2-233): 3.85e-92: 273: 58.62
+	Sp
		314462 PSA2_SCHPO (1-231): 2.14e-104: 303: 53.85		PSA3_SCHPO (1-242): 9.13e-92: 272: 32.79
+	Hs
		700596 PSA6_HUMAN (2-231): 5.68e-102: 297: 32.77		PSA5_HUMAN (2-236): 6.45e-94: 277: 34.17
+	Hs
		681610 PSA6_HUMAN (2-231): 5.68e-102: 297: 32.77		PSA4_HUMAN (1-233): 1.57e-92: 274: 32.49
+	Hs
		954775 PSA6_HUMAN (2-231): 5.68e-102: 297: 32.77		PSA6_HUMAN (1-240): 2.04e-92: 273: 32.11
+	Sc
		661477 PSA2_YEAST (1-231): 1.89e-100: 293: 51.79		PSA5_YEAST (2-248): 4.45e-93: 276: 32.81
+	Hs
		165267 PSA5_HUMAN (3-231): 2.67e-90: 267: 28.57		PSA7_HUMAN (1-234): 4.26e-99: 290: 63.25
+	Sp
		314464 PSA2_SCHPO (1-231): 2.14e-104: 303: 53.85		PSA4_SCHPO (1-252): 1.57e-81: 246: 50.59
+	Dm
		652760 PSA5_DROME (3-231): 2.9e-92: 272: 31.67		PSA71_DROME (2-233): 3.85e-92: 273: 58.62
+	Hv
		1463044 PSA1_HALVD (5-230): 1.66e-90: 268: 34.63		PSA1_HALVD (4-252): 2.93e-93: 276: 36.55
+	Hs
		700556 PSA5_HUMAN (3-231): 2.67e-90: 267: 28.57		PSA5_HUMAN (2-236): 6.45e-94: 277: 34.17
+	Hs
		681576 PSA5_HUMAN (3-231): 2.67e-90: 267: 28.57		PSA4_HUMAN (1-233): 1.57e-92: 274: 32.49
+	Sc
		661525 PSA2_YEAST (1-231): 1.89e-100: 293: 51.79		PSA4_YEAST (1-229): 3.17e-79: 240: 54.70
+	Sp
		1082946 PSA5_SCHPO (3-229): 2.61e-91: 270: 30.38		PSA4_SCHPO (1-252): 1.57e-81: 246: 50.59
+	Hs
		681139 PSA6_HUMAN (2-231): 5.68e-102: 297: 32.77		PSA2_HUMAN (4-186): 1.93e-42: 145: 39.34
+	Hs
		681107 PSA5_HUMAN (3-231): 2.67e-90: 267: 28.57		PSA2_HUMAN (4-186): 1.93e-42: 145: 39.34