Protein: PSA2
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)

Gene: PSA2, PRE8
Organism: Saccharomyces cerevisiae S288C
Interactions: 193
UniProt ID: P23639

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0010499 - proteasomal ubiquitin-independent protein catabolic process
GO:0019773 - proteasome core complex, alpha-subunit complex
GO:0034515 - proteasome storage granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645125

PSB4
Proteasome subunit beta type-4

15

20

Small-scale

0.982

High

661370

PSA3
Proteasome subunit alpha type-3

10

19

Small-scale

0.977

High

636626

PSA1
Proteasome subunit alpha type-1

11

17

Small-scale

0.977

High

661524

PSA6
Proteasome subunit alpha type-6

7

20

High-throughput

0.962

High

661525

PSA4
Proteasome subunit alpha type-4

7

19

High-throughput

0.962

High

661454

PSB2
Proteasome subunit beta type-2

7

20

Small-scale

0.961

High

661457

PSB3
Proteasome subunit beta type-3

7

20

High-throughput

0.960

High

661471

PSB5
Proteasome subunit beta type-5

8

20

Small-scale

0.960

High

636540

PSA7
Probable proteasome subunit alpha type-7

7

20

Small-scale

0.955

High

661477

PSA5
Proteasome subunit alpha type-5

6

19

Small-scale

0.941

High

661472

PSB7
Proteasome subunit beta type-7

5

20

High-throughput

0.922

High

661453

PSB6
Proteasome subunit beta type-6

5

20

High-throughput

0.916

High

661506

UMP1
Proteasome maturation factor UMP1

5

2

Small-scale

0.912

High

661508

PSB1
Proteasome subunit beta type-1

4

20

High-throughput

0.887

High

661533

BLM10
Proteasome activator BLM10

4

6

High-throughput

0.886

High

661575

RPN6
26S proteasome regulatory subunit RPN6

4

20

Small-scale

0.878

High

661488

PRS6B
26S proteasome regulatory subunit 6B homolog

4

20

Small-scale

0.873

High

661572

POC4
Proteasome chaperone 4

3

1

Small-scale

0.847

High

661487

PRS6A
26S proteasome regulatory subunit 6A

3

20

High-throughput

0.827

High

661548

PRS10
26S proteasome subunit RPT4

3

20

High-throughput

0.827

High

661551

PRS8
26S proteasome regulatory subunit 8 homolog

3

20

High-throughput

0.827

High

661573

RPN5
26S proteasome regulatory subunit RPN5

3

19

Small-scale

0.827

High

661568

POC3
Proteasome chaperone 3

2

1

Small-scale

0.768

High

661534

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

13

20

Small-scale

0.756

High

661451

PSA2
Proteasome subunit alpha type-2

2

18

High-throughput

0.754

High

661489

PRS7
26S proteasome regulatory subunit 7 homolog

2

20

High-throughput

0.754

High

661497

POC2
Proteasome assembly chaperone 2

2

1

High-throughput

0.754

High

661526

PRS4
26S proteasome regulatory subunit 4 homolog

2

20

High-throughput

0.754

High

661560

POC1
Proteasome chaperone 1

3

1

High-throughput

0.751

High

661461

FUB1
Silencing boundary-establishment protein FUB1

3

1

Small-scale

0.739

High

661512

ECM29
Proteasome component ECM29

5

11

High-throughput

0.712

High

661515

RPN10
26S proteasome regulatory subunit RPN10

4

10

High-throughput

0.691

High

661513

RPN1
26S proteasome regulatory subunit RPN1

3

20

Small-scale

0.640

High

661570

RPN8
26S proteasome regulatory subunit RPN8

3

19

Small-scale

0.640

High

523114

HSP71
Heat shock protein SSA1

3

8

High-throughput

0.624

High

661462

CDC48
Cell division control protein 48

1

9

High-throughput

0.618

High

661473

HS104
Heat shock protein 104

1

1

High-throughput

0.618

High

661475

IMB3
Importin subunit beta-3

2

0

High-throughput

0.595

High

150262

RPN13
26S proteasome regulatory subunit RPN13

2

1

High-throughput

0.584

High

314843

SEM1
26S proteasome complex subunit SEM1

2

1

High-throughput

0.584

High

661480

RPN12
26S proteasome regulatory subunit RPN12

2

4

High-throughput

0.584

High

661483

RPN2
26S proteasome regulatory subunit RPN2

2

20

High-throughput

0.584

High

661485

RAD23
UV excision repair protein RAD23

2

20

High-throughput

0.584

High

661521

RPN3
26S proteasome regulatory subunit RPN3

2

7

High-throughput

0.584

High

661535

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

2

10

High-throughput

0.584

High

661559

RPN9
26S proteasome regulatory subunit RPN9

2

10

High-throughput

0.584

High

661562

RPN7
26S proteasome regulatory subunit RPN7

2

20

High-throughput

0.584

High

525966

HSP72
Heat shock protein SSA2

2

8

High-throughput

0.571

High

661455

SIS1
Protein SIS1

2

6

High-throughput

0.571

High

661555

EST3
Telomere replication protein EST3

2

0

High-throughput

0.563

High

616388

SEC18
Vesicular-fusion protein SEC18

1

13

High-throughput

0.553

High

661541

CLA4
Serine/threonine-protein kinase CLA4

1

6

High-throughput

0.536

High

578886

HSC82
ATP-dependent molecular chaperone HSC82

2

4

High-throughput

0.533

High

661561

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

2

1

High-throughput

0.533

High

660828

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

High-throughput

0.515

High

661490

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.514

High

517906

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.501

High

661493

NOT4
General negative regulator of transcription subunit 4

1

3

High-throughput

0.501

High

661531

GLDS1
Protein GDS1

1

0

High-throughput

0.493

High

358971

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.479

High

359152

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

High-throughput

0.479

High

392265

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.479

High

434846

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

436324

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

16

High-throughput

0.479

High

590538

HSP26
Heat shock protein 26

1

2

High-throughput

0.479

High

647009

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

661458

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.479

High

661467

CIN8
Kinesin-like protein CIN8

1

4

High-throughput

0.479

High

661469

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

661470

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

661476

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

661484

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.479

High

661494

EF1G2
Elongation factor 1-gamma 2

1

4

High-throughput

0.479

High

661500

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

661528

MOB1
DBF2 kinase activator protein MOB1

1

6

High-throughput

0.479

High

661540

DSK2
Ubiquitin domain-containing protein DSK2

1

20

High-throughput

0.479

High

661545

HUL5
E3 ubiquitin-protein ligase HUL5

1

18

High-throughput

0.479

High

661556

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

661558

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

661576

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

439251

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

486043

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.458

High

503357

RL11A
Large ribosomal subunit protein uL5A

1

0

High-throughput

0.458

High

513328

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.458

High

531608

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.458

High

584887

TRM1
tRNA

1

0

High-throughput

0.458

High

603012

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

655610

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.458

High

661139

SPT6
Transcription elongation factor SPT6

1

0

High-throughput

0.458

High

661459

YIH1
Protein IMPACT homolog

1

0

High-throughput

0.458

High

661464

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

661499

SPO14
Phospholipase D1

1

0

High-throughput

0.458

High

661516

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

661529

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

661542

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.458

High

661544

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.458

High

661546

SWC4
SWR1-complex protein 4

1

0

High-throughput

0.458

High

661547

PBP1
PAB1-binding protein 1

1

0

High-throughput

0.458

High

661549

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.458

High

661563

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

661565

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

661571

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

661502

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.457

High

543876

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

661523

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

367901

ENO2
Enolase 2

1

4

High-throughput

0.437

High

394257

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.437

High

504512

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.437

High

513819

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.437

High

592026

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.437

High

626598

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.437

High

633531

SAR1
Small COPII coat GTPase SAR1

1

1

High-throughput

0.437

High

661463

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

661474

EF2
Elongation factor 2

1

2

High-throughput

0.437

High

661478

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.437

High

661503

KMO
Kynurenine 3-monooxygenase

1

1

High-throughput

0.437

High

661504

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

661514

KOG1
Target of rapamycin complex 1 subunit KOG1

1

3

High-throughput

0.437

High

661517

ATC3
Phospholipid-transporting ATPase DRS2

1

3

High-throughput

0.437

High

661518

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.437

High

661520

BIM1
Protein BIM1

1

2

High-throughput

0.437

High

661522

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

High-throughput

0.437

High

661527

MLP2
Protein MLP2

1

3

High-throughput

0.437

High

661536

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.437

High

661537

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.437

High

661564

TUS1
Rho1 guanine nucleotide exchange factor TUS1

1

3

High-throughput

0.437

High

661495

LHS1
Heat shock protein 70 homolog LHS1

1

9

High-throughput

0.407

High

661519

HSP7E
Heat shock protein SSC3, mitochondrial

1

7

High-throughput

0.407

High

661553

NUP49
Nucleoporin NUP49/NSP49

2

0

Small-scale

0.317

High

661566

VAC14
Vacuole morphology and inheritance protein 14

1

0

High-throughput

0.282

High

661567

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.269

Low

399299

PYRF
Orotidine 5'-phosphate decarboxylase

1

0

High-throughput

0.249

Low

409947

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

427142

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.249

Low

427996

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.249

Low

432493

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.249

Low

432977

RL6B
Large ribosomal subunit protein eL6B

1

0

High-throughput

0.249

Low

433971

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.249

Low

434519

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.249

Low

454278

CARP
Saccharopepsin

1

0

High-throughput

0.249

Low

470011

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

511139

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

511374

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.249

Low

511630

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.249

Low

512013

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.249

Low

512834

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

513458

RL1A
Large ribosomal subunit protein uL1A

1

0

High-throughput

0.249

Low

513633

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

513952

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

514098

RS16B
Small ribosomal subunit protein uS9B

1

0

High-throughput

0.249

Low

514230

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

514470

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

556559

STE6
Alpha-factor-transporting ATPase

1

0

High-throughput

0.249

Low

561664

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.249

Low

569715

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.249

Low

570210

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.249

Low

572518

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.249

Low

613525

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.249

Low

618548

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.249

Low

661452

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

661456

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

661460

SRB8
Mediator of RNA polymerase II transcription subunit 12

1

0

High-throughput

0.249

Low

661465

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.249

Low

661466

RL16B
Large ribosomal subunit protein uL13B

1

0

High-throughput

0.249

Low

661468

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.249

Low

661479

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.249

Low

661481

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.249

Low

661482

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

High-throughput

0.249

Low

661486

ZRT1
Zinc-regulated transporter 1

1

0

High-throughput

0.249

Low

661491

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

661492

TIP20
Protein transport protein TIP20

1

0

High-throughput

0.249

Low

661496

DYHC
Dynein heavy chain, cytoplasmic

1

0

High-throughput

0.249

Low

661498

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.249

Low

661501

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.249

Low

661505

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

661507

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.249

Low

661509

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.249

Low

661510

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

661511

MUP3
Low-affinity methionine permease

1

0

High-throughput

0.249

Low

661530

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

661532

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.249

Low

661538

RS7B
Small ribosomal subunit protein eS7B

1

0

High-throughput

0.249

Low

661539

OST3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3

1

0

High-throughput

0.249

Low

661543

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.249

Low

661550

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.249

Low

661552

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

0

High-throughput

0.249

Low

661554

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

661557

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

661569

SLK19
Kinetochore protein SLK19

1

0

High-throughput

0.249

Low

661574

GLO4
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.249

Low

661577

ZPS1
Protein ZPS1

1

0

High-throughput

0.249

Low

661578

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025