Protein: PSA4
Proteasome subunit alpha type-4 (Macropain subunit PRE6) (Multicatalytic endopeptidase complex subunit PRE6) (Proteasome component PRE6) (Proteinase YSCE subunit PRE6)

Gene: PSA4, PRE6
Organism: Saccharomyces cerevisiae S288C
Interactions: 94
UniProt ID: P40303

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0010499 - proteasomal ubiquitin-independent protein catabolic process
GO:0019773 - proteasome core complex, alpha-subunit complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645176

PSB4
Proteasome subunit beta type-4

20

20

Small-scale

0.988

High

721263

PSB5
Proteasome subunit beta type-5

9

20

Small-scale

0.967

High

636669

PSA1
Proteasome subunit alpha type-1

7

20

Small-scale

0.962

High

661525

PSA2
Proteasome subunit alpha type-2

7

19

High-throughput

0.962

High

636588

PSA7
Probable proteasome subunit alpha type-7

6

20

Small-scale

0.943

High

822005

BLM10
Proteasome activator BLM10

6

7

Small-scale

0.935

High

735935

PSA5
Proteasome subunit alpha type-5

6

19

Small-scale

0.935

High

661413

PSA3
Proteasome subunit alpha type-3

5

19

Small-scale

0.922

High

821967

PSA6
Proteasome subunit alpha type-6

5

19

High-throughput

0.922

High

662045

PSB6
Proteasome subunit beta type-6

4

18

High-throughput

0.896

High

721315

PSB7
Proteasome subunit beta type-7

4

20

Small-scale

0.892

High

822000

PSA4
Proteasome subunit alpha type-4

4

18

Small-scale

0.886

High

750953

PRS7
26S proteasome regulatory subunit 7 homolog

4

20

Small-scale

0.886

High

822029

RPN5
26S proteasome regulatory subunit RPN5

4

20

Small-scale

0.886

High

797529

UMP1
Proteasome maturation factor UMP1

4

2

Small-scale

0.881

High

675250

PSB3
Proteasome subunit beta type-3

3

20

High-throughput

0.855

High

800847

PSB1
Proteasome subunit beta type-1

3

20

High-throughput

0.855

High

750684

PRS6A
26S proteasome regulatory subunit 6A

3

20

High-throughput

0.827

High

822028

POC4
Proteasome chaperone 4

2

1

Small-scale

0.789

High

750847

PRS6B
26S proteasome regulatory subunit 6B homolog

2

20

High-throughput

0.789

High

822030

RPN6
26S proteasome regulatory subunit RPN6

2

20

High-throughput

0.789

High

668395

PSB2
Proteasome subunit beta type-2

2

20

High-throughput

0.776

High

822006

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

12

20

Small-scale

0.755

High

679749

CDC48
Cell division control protein 48

2

11

High-throughput

0.754

High

822001

PRS4
26S proteasome regulatory subunit 4 homolog

2

20

High-throughput

0.754

High

752324

HSP78
Heat shock protein 78, mitochondrial

2

0

High-throughput

0.699

High

803131

ECM29
Proteasome component ECM29

4

13

Small-scale

0.686

High

679050

FUB1
Silencing boundary-establishment protein FUB1

2

1

Small-scale

0.675

High

806731

RPN10
26S proteasome regulatory subunit RPN10

3

11

High-throughput

0.662

High

740171

RPN2
26S proteasome regulatory subunit RPN2

3

20

Small-scale

0.660

High

803568

RPN1
26S proteasome regulatory subunit RPN1

3

20

High-throughput

0.656

High

822021

RPN7
26S proteasome regulatory subunit RPN7

3

20

High-throughput

0.656

High

822025

RPN8
26S proteasome regulatory subunit RPN8

3

20

Small-scale

0.656

High

822023

POC3
Proteasome chaperone 3

1

1

Small-scale

0.647

High

738314

RPN12
26S proteasome regulatory subunit RPN12

3

4

Small-scale

0.640

High

779995

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.618

High

822009

PRS10
26S proteasome subunit RPT4

1

20

High-throughput

0.618

High

822014

PRS8
26S proteasome regulatory subunit 8 homolog

1

20

High-throughput

0.618

High

817061

RPN3
26S proteasome regulatory subunit RPN3

2

8

High-throughput

0.611

High

822019

RPN9
26S proteasome regulatory subunit RPN9

2

12

High-throughput

0.611

High

734681

IMB3
Importin subunit beta-3

2

0

High-throughput

0.595

High

803870

CIC1
Proteasome-interacting protein CIC1

1

0

Small-scale

0.568

High

822020

POC1
Proteasome chaperone 1

1

1

High-throughput

0.553

High

524118

HSP71
Heat shock protein SSA1

2

9

High-throughput

0.552

High

545077

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.552

High

741683

HSP7F
Heat shock protein homolog SSE1

2

12

High-throughput

0.552

High

678399

PWP2
Periodic tryptophan protein 2

2

2

High-throughput

0.537

High

460731

CDC4
Cell division control protein 4

1

7

Small-scale

0.536

High

822010

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.536

High

822012

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

660860

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

High-throughput

0.515

High

699410

CIN8
Kinesin-like protein CIN8

1

5

High-throughput

0.515

High

822003

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

1

High-throughput

0.515

High

779414

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

822022

PIN3
[PSI+] inducibility protein 3

1

2

High-throughput

0.508

High

761115

NOT4
General negative regulator of transcription subunit 4

1

3

High-throughput

0.501

High

150288

RPN13
26S proteasome regulatory subunit RPN13

1

1

High-throughput

0.479

High

435130

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

579494

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

670779

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

707253

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

735005

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

743992

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.479

High

745761

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

750191

UFD4
Ubiquitin fusion degradation protein 4

1

20

Small-scale

0.479

High

779247

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.479

High

822002

MLP2
Protein MLP2

1

4

High-throughput

0.479

High

822007

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

11

High-throughput

0.479

High

822011

H3
Histone H3

1

3

High-throughput

0.479

High

822017

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

822031

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

822032

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.479

High

603062

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

822018

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

822024

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.458

High

822027

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

526833

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

818897

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

441941

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

795381

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.437

High

815349

PAC2
Protein PAC2

1

8

Small-scale

0.437

High

822013

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

822015

VPS60
Vacuolar protein-sorting-associated protein 60

1

4

Small-scale

0.437

High

822026

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

822004

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

625962

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.269

Low

822016

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.261

Low

149797

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

383730

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

455097

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

674659

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

822008

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

744054

ANP1
Mannan polymerase II complex ANP1 subunit

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025