HitPredict

Interactor 1: SNP23 (O00161)
Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)
Gene: SNAP23

Interactor 2: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	25416956, 30833792, 33961781
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 116
+	Hs
		66336 A8K287_HUMAN (1-211): 1.06e-71: 218: 100.00		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Hs
		117995 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18
+	Hs
		117935 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58
+	Hs
		118071 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		VAMP8_HUMAN (2-74): 9.04e-26: 94.2: 26.03
+	Hs
		118017 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		VAMP2_HUMAN (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		118036 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Dm
		1178123 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18
+	At
		1351793 SNP33_ARATH (1-210): 2.42e-60: 192: 22.54		VA721_ARATH (5-92): 9.82e-32: 113: 26.14
+	Rn
		250770 SNP23_RAT (1-211): 6.18e-69: 211: 87.20		VAMP2_RAT (2-75): 2.33e-25: 93.8: 39.19
+	Rn
		250775 SNP23_RAT (1-211): 6.18e-69: 211: 87.20		VAMP8_RAT (2-69): 7.27e-25: 91.9: 27.94
+	Mm
		140167 SNP23_MOUSE (1-211): 2.55e-68: 209: 87.20		VAMP2_MOUSE (2-75): 2.33e-25: 93.8: 39.19
+	At
		812701 SNP33_ARATH (1-210): 2.42e-60: 192: 22.54		VA722_ARATH (5-92): 1.2e-30: 110: 25.00
+	Rn
		250769 SNP23_RAT (1-211): 6.18e-69: 211: 87.20		VAMP3_RAT (2-69): 2.48e-24: 90.7: 39.71
+	Hs
		306744 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Dm
		577245 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Dm
		739423 SNP25_DROME (6-210): 1.87e-57: 182: 50.24		Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18
+	Dm
		577212 SNP25_DROME (6-210): 1.87e-57: 182: 50.24		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Hs
		261624 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58
+	Mm
		926350 SNP29_MOUSE (7-208): 2.08e-56: 181: 18.72		VAMP2_MOUSE (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		263128 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65