HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: SHAN2 (Q80Z38)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1)
Gene: Shank2

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.881

The method score is based on:

Property Details
Experiments 27507650, 28671696, 36417873, 28469556
Identification Methods affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PDZ_6~PDZ_6, SAM_1~SAM_1, SH3_2~SH3_2
Common GO terms GO:0005886 - plasma membrane
GO:0007416 - synapse assembly
GO:0007612 - learning
GO:0007613 - memory
GO:0014069 - postsynaptic density
and 11 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1730
Mm

1 1476
+ Mm
+ Rn
+ Mm
+ Mm
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025