HitPredict

Interactor 1: NOTC3 (Q9UM47)
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Gene: NOTCH3

Interactor 2: NOTC3 (Q9UM47)
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Gene: NOTCH3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.692

The method score is based on:

Property Details
Experiments 26051713
Identification Methods cosedimentation in solution, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ank~Ank, Ank~Ank_2, Ank_2~Ank_2, EGF~EGF, EGF~EGF_CA, EGF~hEGF, EGF_CA~EGF_CA, EGF_CA~hEGF, NOD~NODP, NOD~Notch, NODP~NODP, NODP~Notch, Notch~Notch
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005654 - nucleoplasm
and 18 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 11Aug2025