Protein: LEF1
Lymphoid enhancer-binding factor 1 (LEF-1)

Gene: LEF1
Organism: Mus musculus
Interactions: 23
UniProt ID: P27782

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

697743

CTNB1
Catenin beta-1

6

20

Small-scale

0.940

High

697737

HMGB2
High mobility group protein B2

1

19

Small-scale

0.647

High

666044

PAX3
Paired box protein Pax-3

2

20

Small-scale

0.629

High

697742

TCF7
Transcription factor 7

1

18

Small-scale

0.618

High

697745

SOX17
Transcription factor SOX-17

1

20

Small-scale

0.618

High

697750

TF7L2
Transcription factor 7-like 2

1

18

Small-scale

0.618

High

697751

PIAS4
E3 SUMO-protein ligase PIAS4

2

9

Small-scale

0.606

High

697738

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.549

High

204329

ALX4
Homeobox protein aristaless-like 4

1

20

Small-scale

0.515

High

449635

MYB
Transcriptional activator Myb

1

4

Small-scale

0.515

High

697741

SMAD4
Mothers against decapentaplegic homolog 4

1

20

Small-scale

0.515

High

697744

PAX5
Paired box protein Pax-5

1

20

Small-scale

0.515

High

697746

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.515

High

697747

TLE4
Transducin-like enhancer protein 4

1

20

Small-scale

0.501

High

640752

RAG2
V(D)J recombination-activating protein 2

1

0

Small-scale

0.493

High

486810

CADH1
Cadherin-1

1

3

Small-scale

0.479

High

612488

CDX1
Homeobox protein CDX-1

1

19

Small-scale

0.479

High

625738

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

697748

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

14

High-throughput

0.479

High

697749

DACT2
Dapper homolog 2

1

4

Small-scale

0.479

High

697752

HIPK2
Homeodomain-interacting protein kinase 2

1

10

Small-scale

0.479

High

697739

MDFI
MyoD family inhibitor

1

0

Small-scale

0.458

High

697740

OSTC2
Osteocalcin-2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025