HitPredict

Interactor 1: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Interactor 2: 1433B (Q9CQV8)
14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: Ywhab

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

Property	Details
Experiments	21390248, unassigned1853
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2527 Mm			1 246
+	Mm
		972224 LRRK2_MOUSE (1-2527): 0: 2794: 100.00		1433E_MOUSE (3-243): 1.26e-143: 403: 65.02
+	Mm
		989966 LRRK2_MOUSE (1-2527): 0: 2794: 100.00		1433Z_MOUSE (3-244): 6.08e-142: 398: 86.78
+	Hs
		1209885 LRRK2_HUMAN (1-2527): 0: 2764: 86.60		V9HWD6_HUMAN (1-246): 5.23e-144: 404: 98.78
+	Hs
		729905 LRRK2_HUMAN (1-2527): 0: 2764: 86.60		1433B_HUMAN (1-246): 5.23e-144: 404: 98.78
+	Hs
		971608 LRRK2_HUMAN (1-2527): 0: 2764: 86.60		1433E_HUMAN (3-243): 1.26e-143: 403: 65.02
+	Hs
		990312 LRRK2_HUMAN (1-2527): 0: 2764: 86.60		1433Z_HUMAN (3-244): 2.37e-141: 397: 87.19
+	Mm
		996612 LRRK2_MOUSE (1-2527): 0: 2794: 100.00		1433T_MOUSE (3-244): 1.02e-123: 353: 80.99
+	Hs
		691082 LRRK2_HUMAN (1-2527): 0: 2764: 86.60		1433T_HUMAN (3-244): 2.86e-124: 354: 80.99
+	Mm
		967102 LRRK2_MOUSE (1-2527): 0: 2794: 100.00		1433G_MOUSE (3-246): 8.57e-109: 315: 75.81
+	Mm
		999076 LRRK2_MOUSE (1-2527): 0: 2794: 100.00		1433F_MOUSE (4-244): 4.85e-107: 310: 75.92
+	Hs
		966422 LRRK2_HUMAN (1-2527): 0: 2764: 86.60		1433G_HUMAN (3-246): 8.57e-109: 315: 75.81
+	Hs
		1049374 LRRK2_HUMAN (1-2527): 0: 2764: 86.60		1433F_HUMAN (4-244): 9.98e-107: 310: 75.92
+	Hs
		730644 LRRK2_HUMAN (1-2527): 0: 2764: 86.60		1433S_HUMAN (3-239): 3.72e-99: 290: 68.62
+	At
		1030880 PBS1_ARATH (1881-2133): 6.32e-84: 286: 28.83		14332_ARATH (1-241): 1.13e-144: 406: 62.86
+	Zm
		22653 A0A1D6I257_MAIZE (623-1107): 9.32e-65: 243: 14.92		B6U284_MAIZE (3-243): 1.82e-143: 403: 63.27
+	At
		1030928 BRL2_ARATH (623-1077): 2.25e-49: 196: 10.55		14332_ARATH (1-241): 1.13e-144: 406: 62.86
+	At
		840545 BRL2_ARATH (623-1077): 2.25e-49: 196: 10.55		14333_ARATH (3-241): 1.44e-142: 401: 62.96
+	Hs
		729743 M3K9_HUMAN (1874-2136): 2.59e-23: 110: 32.39		1433B_HUMAN (1-246): 5.23e-144: 404: 98.78
+	Hs
		690900 M3K9_HUMAN (1874-2136): 2.59e-23: 110: 32.39		1433T_HUMAN (3-244): 2.86e-124: 354: 80.99
+	Hs
		730506 M3K9_HUMAN (1874-2136): 2.59e-23: 110: 32.39		1433S_HUMAN (3-239): 3.72e-99: 290: 68.62