HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	24510904, 31046837, 20642453, 24947832
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, protein array
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008104 - intracellular protein localization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 2527
+	Hs
		971608 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Hs
		1209885 V9HWD6_HUMAN (1-246): 3.49e-144: 404: 100.00		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Mm
		972224 1433E_MOUSE (3-243): 4.41e-144: 405: 65.43		LRRK2_MOUSE (1-2527): 0: 2872: 86.36
+	At
		1030922 14332_ARATH (1-241): 4.77e-145: 407: 63.27		CLV1_ARATH (801-1610): 6.55e-142: 472: 14.39
+	At
		198906 14332_ARATH (1-241): 4.77e-145: 407: 63.27		BRI1_ARATH (805-1526): 6.03e-118: 408: 15.67
+	Hs
		840846 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		MATK_HUMAN (1683-2160): 2.38e-106: 352: 20.83
+	At
		840304 14331_ARATH (2-240): 2.72e-143: 403: 62.96		EMS1_ARATH (845-1308): 5.44e-97: 345: 18.96
+	At
		840502 14333_ARATH (3-241): 4.46e-143: 402: 62.96		EMS1_ARATH (845-1308): 5.44e-97: 345: 18.96
+	Hs
		834166 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74
+	Hs
		729657 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74
+	At
		1030880 14332_ARATH (1-241): 4.77e-145: 407: 63.27		PBS1_ARATH (1881-2133): 7.61e-85: 288: 28.21
+	Zm
		22653 B6U284_MAIZE (3-243): 6.64e-144: 404: 63.27		A0A1D6I257_MAIZE (1063-1522): 1.98e-62: 236: 17.91
+	Hs
		972139 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		SHOC2_HUMAN (944-1353): 1.24e-60: 222: 22.27
+	Hs
		730359 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		SHOC2_HUMAN (944-1353): 1.24e-60: 222: 22.27
+	Hs
		971400 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		M3K9_HUMAN (1874-2136): 3.09e-24: 114: 32.38
+	Hs
		729743 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		M3K9_HUMAN (1874-2136): 3.09e-24: 114: 32.38
+	Hs
		971424 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		M3K10_HUMAN (1864-2136): 2.4e-23: 110: 32.20
+	Hs
		729762 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		M3K10_HUMAN (1864-2136): 2.4e-23: 110: 32.20
+	Hs
		213885 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		M3K7_HUMAN (1869-2132): 8.4e-23: 107: 28.83
+	At
		1030928 14332_ARATH (1-241): 4.77e-145: 407: 63.27		BRL2_ARATH (1470-1771): 2.86e-12: 74.7: 8.21