HitPredict

Interactor 1: 1433T (P68254)
14-3-3 protein theta (14-3-3 protein tau)
Gene: Ywhaq

Interactor 2: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	20659021, 21390248, 20642453, unassigned1853
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0044325 - transmembrane transporter binding GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Mm			1 2527
+	Mm
		972224 1433E_MOUSE (2-243): 9.81e-145: 406: 63.93		LRRK2_MOUSE (1-2527): 0: 2794: 100.00
+	Mm
		989966 1433Z_MOUSE (1-245): 1.98e-142: 400: 79.59		LRRK2_MOUSE (1-2527): 0: 2794: 100.00
+	Hs
		971608 1433E_HUMAN (2-243): 9.81e-145: 406: 63.93		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	Hs
		990312 1433Z_HUMAN (1-245): 1.2e-141: 398: 79.18		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	At
		1030880 14332_ARATH (3-243): 6.32e-144: 404: 61.63		PBS1_ARATH (1881-2133): 6.32e-84: 286: 28.83
+	Zm
		22653 B6U284_MAIZE (1-243): 1.76e-143: 403: 60.32		A0A1D6I257_MAIZE (623-1107): 9.32e-65: 243: 14.92
+	At
		1030928 14332_ARATH (3-243): 6.32e-144: 404: 61.63		BRL2_ARATH (623-1077): 2.25e-49: 196: 10.55
+	At
		840545 14333_ARATH (3-243): 6.04e-143: 401: 62.04		BRL2_ARATH (623-1077): 2.25e-49: 196: 10.55
+	Hs
		213885 1433E_HUMAN (2-243): 9.81e-145: 406: 63.93		M3K7_HUMAN (1869-2143): 1.78e-23: 110: 30.14
+	Hs
		971400 1433E_HUMAN (2-243): 9.81e-145: 406: 63.93		M3K9_HUMAN (1874-2136): 2.59e-23: 110: 32.39
+	Hs
		971424 1433E_HUMAN (2-243): 9.81e-145: 406: 63.93		M3K10_HUMAN (1864-2136): 2.55e-22: 107: 32.54
+	Hs
		840846 1433E_HUMAN (2-243): 9.81e-145: 406: 63.93		MATK_HUMAN (1885-2123): 2.29e-22: 105: 30.71
+	At
		198906 14332_ARATH (3-243): 6.32e-144: 404: 61.63		BRI1_ARATH (780-1057): 6.13e-22: 106: 12.13
+	Hs
		690900 1433T_HUMAN (1-245): 7.89e-142: 398: 99.59		M3K9_HUMAN (1874-2136): 2.59e-23: 110: 32.39
+	Hs
		990091 1433Z_HUMAN (1-245): 1.2e-141: 398: 79.18		M3K9_HUMAN (1874-2136): 2.59e-23: 110: 32.39
+	Hs
		690923 1433T_HUMAN (1-245): 7.89e-142: 398: 99.59		M3K10_HUMAN (1864-2136): 2.55e-22: 107: 32.54
+	Hs
		990120 1433Z_HUMAN (1-245): 1.2e-141: 398: 79.18		M3K10_HUMAN (1864-2136): 2.55e-22: 107: 32.54
+	At
		840304 14331_ARATH (3-242): 2e-142: 401: 61.48		EMS1_ARATH (1596-1789): 6.61e-13: 77: 9.05
+	At
		840502 14333_ARATH (3-243): 6.04e-143: 401: 62.04		EMS1_ARATH (1596-1789): 6.61e-13: 77: 9.05
+	At
		1030922 14332_ARATH (3-243): 6.32e-144: 404: 61.63		CLV1_ARATH (612-831): 4.3e-10: 67.7: 11.20