HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.690

Property	Details
Experiments	20642453, 28202711, 23075850, 24947832
Identification Methods	affinity chromatography technology, pull down, fluorescence polarization spectroscopy, isothermal titration calorimetry, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005759 - mitochondrial matrix GO:0005829 - cytosol GO:0008104 - intracellular protein localization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 2527
+	Hs
		971608 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Mm
		972224 1433E_MOUSE (1-244): 2.03e-141: 398: 63.53		LRRK2_MOUSE (1-2527): 0: 2872: 86.36
+	Mm
		967102 1433G_MOUSE (1-247): 3.17e-139: 392: 100.00		LRRK2_MOUSE (1-2527): 0: 2872: 86.36
+	At
		1030922 14332_ARATH (4-244): 1.4e-141: 398: 61.32		CLV1_ARATH (801-1610): 6.55e-142: 472: 14.39
+	At
		198906 14332_ARATH (4-244): 1.4e-141: 398: 61.32		BRI1_ARATH (805-1526): 6.03e-118: 408: 15.67
+	Hs
		840846 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		MATK_HUMAN (1683-2160): 2.38e-106: 352: 20.83
+	At
		840502 14333_ARATH (1-244): 4.42e-142: 400: 61.79		EMS1_ARATH (845-1308): 5.44e-97: 345: 18.96
+	At
		840304 14331_ARATH (4-244): 4.04e-141: 397: 59.67		EMS1_ARATH (845-1308): 5.44e-97: 345: 18.96
+	Hs
		834166 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74
+	Hs
		834164 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74
+	At
		1030880 14332_ARATH (4-244): 1.4e-141: 398: 61.32		PBS1_ARATH (1881-2133): 7.61e-85: 288: 28.21
+	Zm
		22653 B6U284_MAIZE (2-247): 2.85e-141: 397: 59.68		A0A1D6I257_MAIZE (1063-1522): 1.98e-62: 236: 17.91
+	Hs
		972139 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		SHOC2_HUMAN (944-1353): 1.24e-60: 222: 22.27
+	Hs
		971400 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		M3K9_HUMAN (1874-2136): 3.09e-24: 114: 32.38
+	Hs
		971424 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		M3K10_HUMAN (1864-2136): 2.4e-23: 110: 32.20
+	Hs
		966191 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		M3K9_HUMAN (1874-2136): 3.09e-24: 114: 32.38
+	Hs
		213885 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		M3K7_HUMAN (1869-2132): 8.4e-23: 107: 28.83
+	Hs
		966212 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		M3K10_HUMAN (1864-2136): 2.4e-23: 110: 32.20
+	At
		840545 14333_ARATH (1-244): 4.42e-142: 400: 61.79		BRL2_ARATH (1470-1771): 2.86e-12: 74.7: 8.21
+	At
		1030928 14332_ARATH (4-244): 1.4e-141: 398: 61.32		BRL2_ARATH (1470-1771): 2.86e-12: 74.7: 8.21