Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 0.60 0.719

The method score is based on:

Property Details
Experiments 31046837, 20642453, unassigned1853, 23075850, 24725412, 24947832
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000165 - MAPK cascade
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0008104 - intracellular protein localization
and 4 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 255
Hs

1 2527
+ Mm
+ At
+ At
+ Hs
+ Hs
+ At
+ At
+ At
+ Hs
+ Zm
+ Hs
+ Hs
+ Hs
+ At
+ At

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Last updated: 11Aug2025