HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PEAK1 (Q69Z38)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	23452850
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 217 Mm			1 1735
+	Hs
		987945 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		PEAK1_HUMAN (1-1735): 0: 1207: 85.76
+	Hs
		440212 LCK_HUMAN (3-202): 4.02e-36: 134: 27.49		PEAK1_HUMAN (1-1735): 0: 1207: 85.76
+	Hs
		834230 CSK_HUMAN (2-139): 4.26e-24: 100: 36.24		PEAK1_HUMAN (1-1735): 0: 1207: 85.76
+	Hs
		594103 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		PEAK1_HUMAN (1-1735): 0: 1207: 85.76
+	Hs
		463772 LYN_HUMAN (135-215): 9.03e-11: 62.7: 24.10		PEAK1_HUMAN (1-1735): 0: 1207: 85.76
+	Hs
		987750 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		PRAG1_HUMAN (1-817): 6.73e-53: 207: 14.22
+	Mm
		834253 CSK_MOUSE (2-139): 1.13e-23: 99.4: 35.57		PRAG1_MOUSE (1-835): 1.26e-81: 298: 14.24
+	Hs
		463729 LYN_HUMAN (135-215): 9.03e-11: 62.7: 24.10		M3K3_HUMAN (1141-1653): 1.86e-94: 322: 14.72
+	Hs
		987722 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		PEAK3_HUMAN (1642-1732): 3.79e-31: 131: 39.56
+	Hs
		987741 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		NEK8_HUMAN (1456-1646): 3.16e-22: 106: 19.31
+	Hs
		834204 CSK_HUMAN (2-139): 4.26e-24: 100: 36.24		PRAG1_HUMAN (1-817): 6.73e-53: 207: 14.22
+	Hs
		551610 GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54		NFH_HUMAN (696-948): 2.76e-09: 64.5: 15.89
+	Hs
		594036 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		NEK8_HUMAN (1456-1646): 3.16e-22: 106: 19.31
+	Hs
		362313 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		NEK8_HUMAN (1456-1646): 3.16e-22: 106: 19.31
+	Hs
		440612 FYN_HUMAN (161-215): 1.22e-13: 71.1: 31.58		NEK8_HUMAN (1456-1646): 3.16e-22: 106: 19.31
+	Hs
		908881 VAV2_HUMAN (3-56): 6.05e-11: 63.1: 38.18		NEK3_HUMAN (1479-1705): 2.57e-20: 98.8: 19.67
+	Hs
		463088 YES_HUMAN (161-215): 4.3e-12: 66.5: 28.07		KCC2G_HUMAN (1488-1648): 3.09e-17: 89.5: 22.16
+	Hs
		319045 LYN_HUMAN (135-215): 9.03e-11: 62.7: 24.10		K0754_HUMAN (555-929): 5.64e-15: 83.3: 17.00