Protein: NEK8
Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)

Gene: NEK8
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q86SG6

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005929 - cilium

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1228803

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

3

6

High-throughput

0.861

High

1257196

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

2

18

High-throughput

0.811

High

1286370

NEK7
Serine/threonine-protein kinase Nek7

2

19

High-throughput

0.811

High

461651

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

468545

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

303160

RGS20
Regulator of G-protein signaling 20

2

3

High-throughput

0.783

High

1286367

TRI42
Tripartite motif-containing protein 42

2

20

High-throughput

0.700

High

1286369

OXER1
Oxoeicosanoid receptor 1

2

2

High-throughput

0.700

High

1286376

DNJC7
DnaJ homolog subfamily C member 7

1

13

High-throughput

0.691

High

1286365

TRI69
E3 ubiquitin-protein ligase TRIM69

3

5

High-throughput

0.675

High

1286371

NUDC2
NudC domain-containing protein 2

3

7

High-throughput

0.656

High

508213

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

High-throughput

0.647

High

1286368

NEK9
Serine/threonine-protein kinase Nek9

1

19

Small-scale

0.647

High

362313

ABL1
Tyrosine-protein kinase ABL1

1

10

High-throughput

0.618

High

363506

EGFR
Epidermal growth factor receptor

1

14

High-throughput

0.618

High

440612

FYN
Tyrosine-protein kinase Fyn

1

10

High-throughput

0.618

High

822738

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.618

High

1038652

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

16

High-throughput

0.618

High

1158404

CDC37
Hsp90 co-chaperone Cdc37

1

8

High-throughput

0.618

High

1286380

CYBP
Calcyclin-binding protein

2

0

High-throughput

0.585

High

1201985

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

1286377

METH
Methionine synthase

2

1

High-throughput

0.558

High

1198025

KR132
Keratin-associated protein 13-2

2

2

High-throughput

0.553

High

1250251

ATL4
ADAMTS-like protein 4

2

3

High-throughput

0.553

High

367598

CAH2
Carbonic anhydrase 2

1

1

High-throughput

0.536

High

415680

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.536

High

575154

IDE
Insulin-degrading enzyme

1

2

High-throughput

0.536

High

587717

DESP
Desmoplakin

1

20

High-throughput

0.536

High

713404

SPB3
Serpin B3

1

4

High-throughput

0.536

High

730721

1433S
14-3-3 protein sigma

1

20

High-throughput

0.536

High

731775

S10AB
Protein S100-A11

1

6

High-throughput

0.536

High

818747

CAPG
Macrophage-capping protein

1

3

High-throughput

0.536

High

1286374

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.536

High

1286385

CHIP
E3 ubiquitin-protein ligase CHIP

1

8

High-throughput

0.536

High

587129

ITF2
Transcription factor 4

1

2

High-throughput

0.523

High

843717

HD
Huntingtin

1

4

High-throughput

0.515

High

927383

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

220092

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

0

High-throughput

0.513

High

1286373

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

874807

SPB4
Serpin B4

1

4

High-throughput

0.489

High

916292

TXTP
Tricarboxylate transport protein, mitochondrial

1

10

High-throughput

0.489

High

1144048

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.489

High

1286383

DIC
Mitochondrial dicarboxylate carrier

1

12

High-throughput

0.489

High

1286384

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

8

High-throughput

0.489

High

124805

AIP
AH receptor-interacting protein

1

13

High-throughput

0.479

High

346655

TTC4
Tetratricopeptide repeat protein 4

1

20

High-throughput

0.479

High

594036

NCK1
SH2/SH3 adapter protein NCK1

1

12

High-throughput

0.479

High

600848

HSP76
Heat shock 70 kDa protein 6

1

7

High-throughput

0.479

High

761434

HS71L
Heat shock 70 kDa protein 1-like

1

6

High-throughput

0.479

High

987741

GRB2
Growth factor receptor-bound protein 2

1

15

High-throughput

0.479

High

1259311

TBA1A
Tubulin alpha-1A chain

1

13

High-throughput

0.479

High

1286366

NUDC3
NudC domain-containing protein 3

1

7

High-throughput

0.479

High

1286378

UN45A
Protein unc-45 homolog A

1

15

High-throughput

0.479

High

1286379

RPAP3
RNA polymerase II-associated protein 3

1

13

High-throughput

0.479

High

1286381

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1286386

NUDC
Nuclear migration protein nudC

1

7

High-throughput

0.479

High

1286388

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.479

High

1218416

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.458

High

1286382

UXT
Protein UXT

1

0

High-throughput

0.458

High

868724

LEG7
Galectin-7

1

2

High-throughput

0.445

High

731427

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.437

High

1286375

TTC1
Tetratricopeptide repeat protein 1

1

18

High-throughput

0.437

High

1286387

SGT1
Protein SGT1 homolog

1

8

High-throughput

0.437

High

847579

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.279

Low

939801

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.279

Low

1163473

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.279

Low

1286372

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025