HitPredict

Interactor 1: YAF2 (Q8IY57)
YY1-associated factor 2
Gene: YAF2

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.979

Property	Details
Experiments	24457600, 26496610, 27705803, 22325352, 28514442, 27684187, 32296183, 24981860, 33961781, 20696397, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, comigration in non denaturing gel electrophoresis, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 180 Hs			1 336
+	Mm
		1307837 YAF2_MOUSE (1-180): 3.8e-76: 227: 91.67		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Mm
		1208123 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Hs
		987989 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Mm
		193411 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		RING1_MOUSE (6-336): 1.23e-70: 227: 51.49
+	Hs
		1222217 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		718000 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718409 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1108516 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		1222219 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		1197569 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24
+	Hs
		1019331 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		TRI26_HUMAN (36-282): 9.9e-36: 137: 17.90
+	Mm
		1208119 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		PCGF1_MOUSE (28-336): 2.77e-47: 162: 16.56
+	Hs
		718013 RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		585013 RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78		RO52_HUMAN (36-286): 4.69e-43: 156: 13.55
+	Mm
		620789 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		PCGF2_MOUSE (34-332): 2.29e-41: 149: 15.56
+	Hs
		536924 RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78		TRI27_HUMAN (36-282): 4.98e-37: 141: 16.08
+	Mm
		1208122 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		PCGF6_MOUSE (26-296): 1.67e-36: 136: 14.23
+	Dm
		728817 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		PSC_DROME (3-336): 2.34e-33: 132: 17.31
+	Dm
		1374687 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		Q9VV77_DROME (36-334): 1.57e-34: 127: 16.50
+	Dm
		1361718 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		RING1_DROME (208-333): 2.07e-19: 90.5: 41.35