HitPredict

Interactor 1: TGFI1 (Q62219)
Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) (TGF beta-stimulated clone 5) (TSC-5)
Gene: Tgfb1i1

Interactor 2: GIT1 (Q68FF6)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1)
Gene: GIT1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	12153727
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~LIM, GIT1_C~Paxillin
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 461 Mm			1 770
+	Hs
		212742 TGFI1_HUMAN (1-461): 1.21e-101: 313: 91.32		GIT1_HUMAN (1-770): 3.47e-165: 497: 96.36
+	Hs
		253999 LPXN_HUMAN (7-401): 1.33e-54: 188: 23.06		GIT1_HUMAN (1-770): 3.47e-165: 497: 96.36
+	Mm
		1229305 PAXI_MOUSE (345-461): 4.23e-36: 142: 33.33		GIT1_MOUSE (1-770): 1.89e-167: 503: 100.00
+	Hs
		878587 PAXI_HUMAN (345-461): 1.85e-36: 143: 33.33		GIT1_HUMAN (1-770): 3.47e-165: 497: 96.36
+	Hs
		253951 LPXN_HUMAN (7-401): 1.33e-54: 188: 23.06		GIT2_HUMAN (1-768): 2.92e-142: 438: 63.71
+	Dm
		1304231 Q8INW7_DROME (1-461): 6.14e-117: 355: 40.66		GIT_DROME (9-642): 1.59e-65: 233: 33.38
+	Hs
		878456 PAXI_HUMAN (345-461): 1.85e-36: 143: 33.33		GIT2_HUMAN (1-768): 2.92e-142: 438: 63.71
+	Hs
		1260594 ZN534_HUMAN (70-459): 8.95e-111: 343: 10.98		AGAP1_HUMAN (2-236): 4e-55: 206: 31.93
+	Hs
		71018 ZN724_HUMAN (111-459): 7.66e-105: 326: 8.74		AN36B_HUMAN (76-667): 6.99e-56: 210: 14.07
+	Hs
		1044429 ZNF92_HUMAN (196-459): 7.13e-64: 218: 11.26		AN36B_HUMAN (76-667): 6.99e-56: 210: 14.07
+	Hs
		585113 ZN250_HUMAN (35-427): 1.19e-82: 267: 11.03		ANR50_HUMAN (180-513): 6.65e-26: 116: 12.47
+	Hs
		878581 PAXI_HUMAN (345-461): 1.85e-36: 143: 33.33		ASAP1_HUMAN (2-652): 1.07e-56: 212: 14.57
+	Hs
		207916 PAXI_HUMAN (345-461): 1.85e-36: 143: 33.33		ASAP2_HUMAN (2-543): 3.23e-50: 192: 16.26
+	Dm
		56373 ZASP_DROME (344-460): 9.39e-11: 66.6: 31.93		CEG1A_DROME (1-213): 3.47e-56: 210: 28.70
+	Hs
		1030644 ZYX_HUMAN (344-461): 4.48e-22: 101: 35.54		ANK2_HUMAN (90-573): 8.41e-32: 136: 11.91
+	Hs
		1156218 ZYX_HUMAN (344-461): 4.48e-22: 101: 35.54		TANC2_HUMAN (179-479): 2.97e-15: 82.6: 11.18
+	Hs
		1116593 FHL3_HUMAN (250-461): 3.77e-20: 92: 27.32		TANC2_HUMAN (179-479): 2.97e-15: 82.6: 11.18