HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	27705803, 33961781, 36931259, 28514442, 21282530
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019899 - enzyme binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 560 Hs			1 246
+	Hs
		123219 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		123218 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		123226 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		123189 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		123184 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		123190 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20
+	Mm
		935508 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		1433F_MOUSE (1-246): 6.15e-136: 383: 99.19
+	Mm
		926802 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		1433Z_MOUSE (3-245): 5.23e-108: 313: 74.49