HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: SYP2L (Q9H987)
Synaptopodin 2-like protein
Gene: SYNPO2L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030018 - Z disc
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 892 Hs			1 977
+	Hs
		1061559 ACTN3_HUMAN (18-892): 0: 625: 78.51		SYP2L_HUMAN (1-977): 1.05e-81: 287: 100.00
+	Hs
		773786 ACTN2_HUMAN (10-892): 0: 624: 80.29		SYP2L_HUMAN (1-977): 1.05e-81: 287: 100.00
+	Hs
		555767 ACTN1_HUMAN (1-892): 0: 681: 100.00		PDLI7_HUMAN (5-229): 1.26e-52: 193: 26.09
+	Mm
		1274482 ACTN1_MOUSE (1-892): 0: 677: 99.22		PDLI5_MOUSE (9-218): 6.52e-41: 161: 25.57
+	Rn
		1231096 ACTN1_RAT (1-892): 0: 681: 99.33		PDLI2_RAT (7-210): 1.02e-39: 152: 25.81
+	Hs
		270701 ACTN1_HUMAN (1-892): 0: 681: 100.00		LDB3_HUMAN (6-559): 2.22e-34: 143: 16.25
+	Hs
		555639 ACTN1_HUMAN (1-892): 0: 681: 100.00		PDLI4_HUMAN (9-221): 6.69e-35: 138: 27.70
+	Hs
		224806 ACTN4_HUMAN (11-892): 0: 625: 86.74		PDLI7_HUMAN (5-229): 1.26e-52: 193: 26.09
+	Hs
		773790 ACTN2_HUMAN (10-892): 0: 624: 80.29		PDLI7_HUMAN (5-229): 1.26e-52: 193: 26.09
+	Hs
		123214 ACTN1_HUMAN (1-892): 0: 681: 100.00		PDLI1_HUMAN (8-237): 5.71e-30: 123: 17.48
+	Hs
		773801 ACTN2_HUMAN (10-892): 0: 624: 80.29		SYNP2_HUMAN (209-973): 5.11e-40: 162: 25.37
+	Rn
		1231095 ACTN4_RAT (11-892): 0: 622: 86.40		PDLI2_RAT (7-210): 1.02e-39: 152: 25.81
+	Hs
		270703 ACTN2_HUMAN (10-892): 0: 624: 80.29		LDB3_HUMAN (6-559): 2.22e-34: 143: 16.25
+	Mm
		1440839 ACTN2_MOUSE (10-892): 0: 627: 80.63		LDB3_MOUSE (6-559): 1.06e-31: 135: 16.97
+	Hs
		555718 ACTN1_HUMAN (1-892): 0: 681: 100.00		SYNPO_HUMAN (141-975): 9.56e-11: 68.2: 12.31
+	Hs
		123201 ACTN4_HUMAN (11-892): 0: 625: 86.74		PDLI1_HUMAN (8-237): 5.71e-30: 123: 17.48
+	Hs
		123242 ACTN3_HUMAN (18-892): 0: 625: 78.51		PDLI1_HUMAN (8-237): 5.71e-30: 123: 17.48
+	Hs
		123228 ACTN2_HUMAN (10-892): 0: 624: 80.29		PDLI1_HUMAN (8-237): 5.71e-30: 123: 17.48
+	Hs
		773748 ACTN2_HUMAN (10-892): 0: 624: 80.29		PDLI3_HUMAN (8-106): 2.69e-29: 122: 38.38
+	Hs
		224746 ACTN4_HUMAN (11-892): 0: 625: 86.74		SYNPO_HUMAN (141-975): 9.56e-11: 68.2: 12.31