HitPredict

Interactor 1: DTLB (Q6GPU3)
Denticleless protein homolog B
Gene: dtl-b

Interactor 2: DDB1 (Q6P6Z0)
DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1)
Gene: DDB1

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	16949367, 20606006
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	MMS1_N~WD40, CPSF_A~WD40
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex GO:0031465 - Cul4B-RING E3 ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0048511 - rhythmic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 711 Xl			1 1140
+	Hs
		1157970 DTL_HUMAN (1-711): 9.67e-111: 353: 54.34		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		1085662 TBL3_HUMAN (17-551): 1.47e-78: 269: 12.07		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		964975 WDR5_HUMAN (2-244): 1.68e-58: 202: 14.55		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		1157912 TBL1R_HUMAN (191-485): 1.7e-37: 149: 13.47		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		1157795 WDR5B_HUMAN (301-505): 4.83e-37: 143: 18.05		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		845309 LIS1_HUMAN (312-520): 3.23e-35: 140: 13.33		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		1157860 SNR40_HUMAN (269-438): 3.01e-28: 118: 18.82		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Hs
		261411 TBL1X_HUMAN (261-495): 8.05e-23: 105: 13.14		DDB1_HUMAN (1-1140): 0: 1399: 93.42
+	Dm
		1479749 WDR12_DROME (47-356): 2.2e-24: 108: 14.37		DDB1_DROME (1-1140): 0: 1221: 60.66
+	Dm
		1173998 L2DTL_DROME (16-246): 9.54e-23: 105: 11.22		DDB1_DROME (1-1140): 0: 1221: 60.66
+	Ce
		1170292 Q22059_CAEEL (48-657): 1.64e-68: 239: 19.73		DDB1_CAEEL (1-1140): 0: 1013: 37.30
+	Hs
		1148066 NLE1_HUMAN (344-498): 9.28e-24: 107: 15.39		SF3B3_HUMAN (3-1136): 0: 1078: 21.59
+	Hs
		284949 TAF5L_HUMAN (64-171): 3.26e-09: 62: 32.41		SF3B3_HUMAN (3-1136): 0: 1078: 21.59
+	Sp
		151711 CDT2_SCHPO (52-414): 5.47e-80: 265: 24.68		DDB1_SCHPO (5-1140): 0: 817: 24.37
+	Sp
		207296 PRP17_SCHPO (4-300): 2.5e-23: 106: 12.22		RSE1_SCHPO (3-1136): 0: 923: 20.57
+	Sc
		829958 PRP17_YEAST (86-388): 1.23e-61: 215: 19.87		RSE1_YEAST (3-1136): 0: 687: 15.60
+	Hs
		1083446 NLE1_HUMAN (344-498): 9.28e-24: 107: 15.39		CPSF1_HUMAN (638-1133): 1.55e-118: 401: 20.15