HitPredict

Interactor 1: MDEAS (Q6PJG2)
Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)
Gene: MIDEAS

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	26496610, 35271311, 21258344, 23752268, 26949739
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl
Common GO terms	GO:0000118 - histone deacetylase complex GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1045 Hs			1 488
+	Hs
		1109827 MDEAS_HUMAN (1-1045): 4.65e-153: 483: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1368092 MTA3_HUMAN (685-1043): 6.92e-90: 302: 14.43		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1102617 MTA1_HUMAN (682-1043): 5.82e-75: 264: 13.92		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1277269 MIER3_HUMAN (660-1012): 1.36e-76: 264: 17.11		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		1000040 MTA2_MOUSE (682-1043): 1.22e-74: 262: 14.58		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		316935 MTA2_HUMAN (682-1043): 5.39e-73: 257: 14.32		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1322540 MIER1_HUMAN (660-1038): 2.47e-73: 254: 17.96		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		1000031 MTA1_MOUSE (682-1043): 3.91e-72: 256: 14.43		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		95906 E7EQY4_HUMAN (685-1043): 1.01e-96: 317: 14.47		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1109999 TREF1_HUMAN (99-1045): 1.5e-87: 308: 25.05		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1110039 MTA3_HUMAN (685-1043): 6.92e-90: 302: 14.43		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		148739 MTA2_MOUSE (682-1043): 1.22e-74: 262: 14.58		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1102528 MTA1_HUMAN (682-1043): 5.82e-75: 264: 13.92		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1109844 MIER3_HUMAN (660-1012): 1.36e-76: 264: 17.11		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		148724 MTA1_MOUSE (682-1043): 3.91e-72: 256: 14.43		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		316845 MTA2_HUMAN (682-1043): 5.39e-73: 257: 14.32		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1109884 MIER1_HUMAN (660-1038): 2.47e-73: 254: 17.96		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		1374489 Q9VNF6_DROME (682-1005): 1.19e-62: 231: 14.12		HDAC1_DROME (5-472): 0: 653: 77.92
+	Dm
		84936 B7Z0T5_DROME (682-1005): 6.91e-62: 229: 14.12		HDAC1_DROME (5-472): 0: 653: 77.92
+	Ce
		196421 Q86S28_CAEEL (746-1014): 7.47e-56: 211: 12.00		HDA1_CAEEL (7-456): 0: 595: 64.02