HitPredict

Interactor 1: SI1L1 (O43166)
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)
Gene: SIPA1L1

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27173435, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1804 Hs			1 1824
+	Hs
		876525 SI1L2_HUMAN (1-1802): 0: 1277: 47.91		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		230226 SI1L3_HUMAN (9-1797): 0: 1005: 44.00		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		812870 RPGP1_HUMAN (394-825): 7.82e-113: 376: 32.41		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		196511 SI1L1_HUMAN (1-1804): 0: 1398: 100.00		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Hs
		196430 SI1L1_HUMAN (1-1804): 0: 1398: 100.00		DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51
+	Hs
		196436 SI1L1_HUMAN (1-1804): 0: 1398: 100.00		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Mm
		1143412 SI1L1_MOUSE (1-1804): 0: 1359: 94.51		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		297818 K0754_HUMAN (1315-1795): 2.01e-29: 131: 7.63		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		230245 SI1L3_HUMAN (9-1797): 0: 1005: 44.00		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Dm
		114646 M9PD17_DROME (23-822): 0: 602: 16.28		PATJ_DROME (969-1164): 1.83e-29: 129: 28.08
+	Hs
		1066194 RGPA2_HUMAN (300-839): 3.18e-132: 458: 16.90		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		835084 TSC2_HUMAN (103-864): 2.82e-172: 572: 14.02		INADL_HUMAN (1003-1089): 2.08e-11: 71.8: 25.81
+	Hs
		1102434 RGPA2_HUMAN (300-839): 3.18e-132: 458: 16.90		DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25
+	Ce
		105545 H2L055_CAEEL (349-875): 8e-144: 467: 28.71		DLG1_CAEEL (1010-1092): 1.62e-13: 78.3: 27.06
+	Hs
		1151770 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25
+	Hs
		1066313 MICA3_HUMAN (1083-1731): 3.09e-13: 77.5: 12.16		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		1066964 PCLO_HUMAN (1009-1740): 1.16e-11: 72.7: 11.66		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Ce
		103468 TTN1_CAEEL (1444-1795): 3.05e-12: 74.8: 12.81		DLG1_CAEEL (1010-1092): 1.62e-13: 78.3: 27.06