HitPredict

Interactor 1: WASF1 (Q92558)
Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)
Gene: WASF1

Interactor 2: CYFP2 (Q96F07)
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Gene: CYFIP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FragX_IP~WH2
Common GO terms	GO:0005829 - cytosol GO:0031209 - SCAR complex GO:0051388 - positive regulation of neurotrophin TRK receptor signaling pathway GO:0097484 - dendrite extension
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 559 Hs			1 1278
+	Mm
		1131096 WASF2_MOUSE (1-374): 2.98e-111: 342: 46.19		CYFP2_MOUSE (1-1278): 0: 2126: 97.97
+	Mm
		1131134 WASF1_MOUSE (1-559): 8.6e-72: 241: 98.39		CYFP2_MOUSE (1-1278): 0: 2126: 97.97
+	Bt
		94414 WASF1_BOVIN (1-559): 1.48e-72: 243: 99.46		F1MX60_BOVIN (1-1278): 0: 2120: 97.81
+	Hs
		1290818 WASF3_HUMAN (1-557): 1.12e-43: 164: 45.73		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		1290821 WASF2_HUMAN (1-541): 2.37e-42: 160: 42.14		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		1184637 WASF1_HUMAN (1-559): 2.63e-73: 245: 100.00		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Mm
		1186404 WASF1_MOUSE (1-559): 8.6e-72: 241: 98.39		CYFP1_MOUSE (1-1277): 0: 2032: 85.68
+	Hs
		1184673 WASF3_HUMAN (1-557): 1.12e-43: 164: 45.73		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		1184678 WASF2_HUMAN (1-541): 2.37e-42: 160: 42.14		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Dm
		94639 F2FB81_DROME (1-542): 1.87e-49: 183: 23.93		CYFIP_DROME (1-1277): 0: 1898: 64.75
+	Dd
		1122141 SCAR_DICDI (24-358): 7.66e-34: 135: 20.77		PIRA_DICDI (7-1249): 0: 1445: 36.98